Skip to main content

Advertisement

Table 1 Glycemia and mortality in three randomized controlled trials to assess the benefit of intensive insulin therapy

From: Is reducing variability of blood glucose the real but hidden target of intensive insulin therapy?

  Glycemic control, mmol/La Insulin protocol application Mortality  
  Conventional IIT Conventional IIT Conventional IIT P value
Leuven I trial [7] 8.5 ± 1.8 5.7 ± 1.1 307/783
(39.2%)
755/765
(98.7%)
63/783
(8.0%)
35/765
(4.6%)
<0.04
Leuven II trial [8] 8.5 ± 1.7 6.2 ± 1.6 426/605 <0.04 580/595
(98%)
162/605
(26.8%)
144/595
(24.2%)
0.31
VISEP study [13] 8.4 ± 1.8 6.2 ± 1.0 215/290
(74.1%)
243/247
(98.4%)
75/289
(26.0%)
61/247
(24.7%)
0.74
  1. aGlycemic control values are presented as mean ± standard deviation. IIT, intensive insulin therapy; VISEP, Efficacy of Volume Substitution and Insulin Therapy in Severe Sepsis.