Table 4 Time course to endpoints other than procalcitonin in bacterial sepsis patients according to antibiotic therapy

D1

   SOFA score (points)

6.2 (3.5)

6.4 (4.0)

0.77

   Mean arterial pressure (mmHg)

74.2 (18.7)

71.3 (21.3)

0.41

   Platelet count (giga/l)

201.4 (123.0)

231.4 (175.2)

0.23

   Creatininemia (μmol/l)

197.7 (184.2)

203.6 (173.5)

0.85

   Lactate (mmol/l)

3.4 (3.2)

2.8 (1.8)

0.26

   PO₂/FiO₂ (mmHg)

229 (129)

280 (163)

0.05

   C-reactive protein (mg/l)

159.9 (112.9)

121.1 (105.0)

0.11

D2

   SOFA score (points)

6.0 (3.8)

6.1 (4.3)

0.89

   Mean arterial pressure (mmHg)

78.6 (18.6)

76.2 (18.7)

0.48

   Platelet count (giga/l)

193.0 (128.9)

194.8 (159.9)

0.94

   Creatininemia (μmol/l)

183.9 (175.7)

206.0 (185.5)

0.49

   Lactate (mmol/l)

2.8 (2.8)

2.1 (0.8)

0.15

   PO₂/FiO₂ (mmHg)

252 (132)

251 (129)

0.96

   C-reactive protein (mg/l)

171.7 (101.8)

159.3 (86.6)

0.59

D3

   SOFA score (points)

5.5 (4.0)

5.7 (4.2)

0.73

   Mean arterial pressure (mmHg)

82.3 (19.1)

78.2 (22.3)

0.26

   Platelet count (giga/l)

192.1 (127.6)

177.6 (144.2)

0.55

   Creatininemia (μmol/l)

173.0 (151.9)

199.9 (189.3)

0.35

   Lactate (mmol/l)

2.4 (2.8)

1.8 (0.7)

0.24

   PO₂/FiO₂ (mmHg)

263 (120.7)

275 (108.6)

0.61

   C-reactive protein (mg/l)

176.4 (116.4)

160.0 (86.1)

0.53

D4

   SOFA score (points)

4.5 (3.8)

5.8 (3.9)

0.24

   Mean arterial pressure (mmHg)

81.1 (26.8)

77.0 (14.1)

0.53

   Platelet count (giga/l)

189.8 (139.3)

135.8 (122.9)

0.14

   Creatininemia (μmol/l)

181.1 (161.4)

216.6 (166.7)

0.39

   Lactate (mmol/l)

2.6 (3.5)

1.5 (0.5)

0.09

   PO₂/FiO₂ (mmHg)

249 (122.5)

276 (79)

0.36

   C-reactive protein (mg/l)

139.8 (103.7)

122.2 (74.5)

0.48