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Table 3 Histopathological scoring of osmotic nephrosis-like lesions, proliferating nuclear antigen and activated macrophages

From: Hydroxyethylstarch impairs renal function and induces interstitial proliferation, macrophage infiltration and tubular damage in an isolated renal perfusion model

 

HES 200

HES 130

RL

OL (score)

2.1 ± 0.6

2.0 ± 0.5

1.1 ± 0.4a

PCNA (pc/vf)

18.8 ± 7.1

7.2 ± 1.7b

14.1 ± 4.1

   Interstitial

18.0 ± 6.9

6.5 ± 1.6c

13.5 ± 4.0

   Glomerular

1.2 ± 0.7

1.0 ± 0.3

0.9 ± 0.2

ED-1 (pc/vf)

1.3 ± 1.0

0.2 ± 0.04d

0.4 ± 0.3

  1. Data are presented as mean ± standard deviation.
  2. a RL vs. 10% HES 200/0.5 and RL vs. 6% HES 130/0.42; P = 0.002
  3. b 6% HES 130/0.42 vs. 10% HES 200/0.5; P = 0.008
  4. c 6% HES 130/0.42 vs. 10% HES 200/0.5; P = 0.006
  5. d 6% HES 130/0.42 vs. 10% HES 200/0.5; P = 0.044
  6. ED-1 = activated macrophages; HES = hydroxyethyl starch; OL = osmotic nephrosis-like lesions; PCNA = proliferating nuclear antigen; RL = Ringer's lactate.
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Critical Care

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