Hydroxyethylstarch impairs renal function and induces interstitial proliferation, macrophage infiltration and tubular damage in an isolated renal perfusion model

Table 2 Diuresis, creatinine clearance and sodium transport during isolated renal perfusion over the period of six hours

	Time (hours)	0	2	4	6
Diuresis (μl/min/g)
	HES 200/0.5	0.6 ± 1.2	0.2 ± 0.3	0.2 ± 0.2^b	0.2 ± 0.1^b
	HES 130/0.42	3.0 ± 1.6	3.9 ± 2.6	3.6 ± 1.6	3.7 ± 1.6
	RL	30.4 ± 12.1^a	20.2 ± 15.4^a	5.0 ± 2.8	9.0 ± 5.6
Cl _Crea (ml/min/g)
	HES 200/0.5	0.01 ± 0.01	0.01 ± 0.01^d	0.01 ± 0.01^d	0.01 ± 0.01^d
	HES 130/0.42	0.5 ± 0.07	0.33 ± 0.08	0.13 ± 0.02	0.09 ± 0.01
	RL	1.02 ± 0.12^c	0.21 ± 0.03	0.12 ± 0.03	0.11 ± 0.05
Tr _Na (mmol/min/g)
	HES 200/0.5	-0.6 ± 0.5	-0.2 ± 0.1	-0.1 ± 0.07^b	-0.1 ± 0.04^b
	HES 130/0.42	-3.7 ± 0.9	-3.8 ± 0.8	-4.3 ± 0.7	-4.6 ± 0.7
	RL	-29.3 ± 5.8^c	-15.4 ± 6.0^d	-3.8 ± 1.0	-7.0 ± 6.5

Data are presented as mean ± standard deviation.
^a RL vs. 10% HES 200/0.5 and RL vs. 6% HES 130/0.42; P < 0.01
^b 10% HES 200/0.5 vs. RL and 10% HES 200/0.5 vs. 6% HES 130/0.42; P < 0.01
^c RL vs. 6% HES 130/0.42 and RL vs. 10% HES 200/0.5; P < 0.001
^d 10% HES 200/0.5 vs. RL and 10% HES 200/0.5 vs. 6% HES 130/0.42; P < 0.05
Cl_Crea = creatinine clearance; HES = hydroxyethyl starch; RL = Ringer's lactate; Tr_Na = sodium transport.

ISSN: 1364-8535