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Table 2 Diuresis, creatinine clearance and sodium transport during isolated renal perfusion over the period of six hours

From: Hydroxyethylstarch impairs renal function and induces interstitial proliferation, macrophage infiltration and tubular damage in an isolated renal perfusion model

  Time (hours) 0 2 4 6
Diuresis (μl/min/g)      
  HES 200/0.5 0.6 ± 1.2 0.2 ± 0.3 0.2 ± 0.2b 0.2 ± 0.1b
  HES 130/0.42 3.0 ± 1.6 3.9 ± 2.6 3.6 ± 1.6 3.7 ± 1.6
  RL 30.4 ± 12.1a 20.2 ± 15.4a 5.0 ± 2.8 9.0 ± 5.6
Cl Crea (ml/min/g)      
  HES 200/0.5 0.01 ± 0.01 0.01 ± 0.01d 0.01 ± 0.01d 0.01 ± 0.01d
  HES 130/0.42 0.5 ± 0.07 0.33 ± 0.08 0.13 ± 0.02 0.09 ± 0.01
  RL 1.02 ± 0.12c 0.21 ± 0.03 0.12 ± 0.03 0.11 ± 0.05
Tr Na (mmol/min/g)      
  HES 200/0.5 -0.6 ± 0.5 -0.2 ± 0.1 -0.1 ± 0.07b -0.1 ± 0.04b
  HES 130/0.42 -3.7 ± 0.9 -3.8 ± 0.8 -4.3 ± 0.7 -4.6 ± 0.7
  RL -29.3 ± 5.8c -15.4 ± 6.0d -3.8 ± 1.0 -7.0 ± 6.5
  1. Data are presented as mean ± standard deviation.
  2. a RL vs. 10% HES 200/0.5 and RL vs. 6% HES 130/0.42; P < 0.01
  3. b 10% HES 200/0.5 vs. RL and 10% HES 200/0.5 vs. 6% HES 130/0.42; P < 0.01
  4. c RL vs. 6% HES 130/0.42 and RL vs. 10% HES 200/0.5; P < 0.001
  5. d 10% HES 200/0.5 vs. RL and 10% HES 200/0.5 vs. 6% HES 130/0.42; P < 0.05
  6. ClCrea = creatinine clearance; HES = hydroxyethyl starch; RL = Ringer's lactate; TrNa = sodium transport.