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Figure 1 | Critical Care

Figure 1

From: Bench-to-bedside review: Nitric oxide in critical illness – update 2008

Figure 1

Direct and indirect actions of nitric oxide. Nitric oxide (NO) has direct effects on metal complexes and alkyl radicals, including guanylate cyclase, cytochromes, and lipid radicals. NO also has indirect actions through nitration to form nitrotyrosine, through nitrosation to form nitrosothiols and nitrosamines, and through combination with oxidative radicals, with the potential for subsequent peroxidation of lipids, DNA strand breaks, and hydroxylation. eNOS, endothelial NO synthase; iNOS, inducible NO synthase; nNOS, neuronal NO synthase; O2-, superoxide. Reprinted from Free Radical Biology and Medicine, 45(1), Douglas D. Thomas, Lisa A. Ridnour, Jeffrey S. Isenberg, Wilmarie Flores-Santana, Christopher H. Switzer, Sonia Donzelli, Perwez Hussain, Cecilia Vecoli, Nazareno Paolocci, Stefan Ambs, Carol A. Colton, Curtis C. Harris, David D. Roberts and David A. Wink, The chemical biology of nitric oxide: Implications in cellular signaling, 14 Pages, Copyright (2008), with permission from Elsevier.

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