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Table 2 Changes in gas exchange, cardiovascular and respiratory variables before and during interventional lung assist (iLA) treatment

From: Pumpless extracorporeal interventional lung assist in patients with acute respiratory distress syndrome: a prospective pilot study

 

Pre-iLA

2 hours after insertion

24 hours after insertion

PaO2/FiO2

75 (62 to 130)

102 (70 to 127) *

110 (86 to 160) *

PaCO2 (mmHg)

73 (61 to 86)

44 (36 to 54) **

41 (34 to 48) **

Arterial pH

7.23 (7.16 to 7.30)

7.38 (7.32 to 7.46) **

7.44 (7.37 to 7.49) **§

MAP (mmHg)

73 (65 to 80)

83 (75 to 91) **

81 (76 to 90)

Noradrenaline (μg/kg/minute)

0.16 (0.04 to 0.35)

0.11 (0.03 to 0.28)

0.09 (0.02 to 0.24) *

iLA-flow (L/minute)

-

1.8 (1.6 to 2.0)

1.7 (1.5 to 2.0)

FiO2

1 (0.8 to 1.0)

0.8 (0.7 to 1.0) **

0.7 (0.6 to 0.9) **§S

MV (L/minute)

11.5 (9.3 to 12.5)

8.6 (6.4 to 10.5) **

6.6 (5.5 to 8.3) **§S

VT ml/IBW

6.6 (5.3 to 7.2)

5.0 (4.0 to 6.4) **

4.4 (3.4 to 5.4) **§S

RR (breaths/minute)

25 (22 to 27)

23 (20 to 30)

21 (18 to 26)

Pplat (cmH2O)

35 (31 to 38)

34 (30 to 37)

30 (26 to 34) **

PEEP (cmH2O)

17 (14 to 20)

15 (11 to 19) *

17 (14 to 20)

  1. Variables are presented as median values (interquartile ranges).
  2. * p < 0.05 in comparison with pre-iLA
  3. ** p < 0.01 in comparison with pre-iLA
  4. §p < 0.05 in comparison with two hours after insertion
  5. §S p < 0.01 in comparison with two hours after insertion
  6. FiO2 = fraction of inspired oxygen; MAP = mean arterial pressure; MV = minute ventilation; PaCO2 = partial pressure of carbon dioxide in arterial blood; PaO2 = partial pressure of oxygen in arterial blood; Pplat = plateau pressure; PEEP = positive end expiratory pressure; RR = respiratory rate; VT = tidal volume.