Bench-to-bedside review: Hydrogen sulfide – the third gaseous transmitter: applications for critical care

Table 3 Lung tissue concentrations of inflammatory chemokines after inhaling H₂S during normothermia or hypothermia

	Control, 38°C	H₂S, 38°C	Control, 27°C	H₂S, 27°C
TNFα (pg/mg protein)	67 (52 to 90)	75 (60 to 88)	76 (54 to 88)	71 (60 to 81)
IL-6 (pg/mg protein)	449 (264 to 713)	366 (252 to 483)	338 (140 to 500)	260 (192 to 339)*
MCP-1 (pg/mg protein)	194 (102 to 280)	114 (77 to 138)*	99 (68 to 168)*	106 (48 to 150)*
MIP-2 (pg/mg protein)	613 (278 to 1049)	284 (214 to 357)*	306 (231 to 376)*	283 (248 to 373)*
KC (pg/mg protein)	435 (268 to 602)	296 (255 to 332)*	309 (217 to 401)*	329 (301 to 366)*

Lung tissue concentrations of monocyte chemotactic protein-1 (MCP-1), macrophage-inflammatory protein-2 (MIP-2), growth-related oncogen/keratinocyte-derived chemokine (KC), TNF α, and IL-6 after inhaling hydrogen sulfide (H₂S) (100 ppm over 5 hours) during normothermia (38°C) or hypothermia (27°C) [83]. Data presented as median (range), n = 5 in each group. *P < 0.05 versus control, 38°C.