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Table 2 Cardiac effects of inhaled H2S in anesthetized and mechanically ventilated mice during normothermia and hypothermia

From: Bench-to-bedside review: Hydrogen sulfide – the third gaseous transmitter: applications for critical care

 

Control, 38°C

H2S, 38°C

Control, 27°C

H2S, 27°C

Heart rate (beats/min)

350 (289 to 437)

324 (274 to 387)

112 (96 to 305)*

116 (96 to 327)*

Mean arterial pressure (mmHg)

62 (57 to 72)

60 (57 to 65)

45 (37 to 63)*

48 (41 to 59)*

Stroke volume (μl)

33 (19 to 62)

29 (23 to 53)

27 (21 to 39)

25 (20 to 32)

Ejection fraction (%)

45 (38 to 55)

40 (35 to 48)

50 (37 to 57)

47 (35 to 54)

End-diastolic pressure (mmHg)

16 (12 to 18)

15 (12 to 16)

15 (11 to 22)

14 (11 to 18)

  1. Cardiac effects of inhaled hydrogen sulfide (H2S) (100 ppm over 5 hours) in anesthetized and mechanically ventilated mice instrumented with left ventricular pressure volume conductance catheters during normothermia (38°C) and hypothermia (27°C) [62]. Data presented as median (range), n = 8 in each group. *P < 0.05 versus control, 38°C.
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Critical Care

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