Figure 4
From: Novel polymorphism of interleukin-18 associated with greater inflammation after cardiac surgery
Serum concentrations of interleukin (IL)-18, tumour necrosis factor (TNF)-α and IL-10 by IL-18 9545 T/G genotype in Caucasian patients who underwent on-pump cardiopulmonary bypass (CPB) surgery. Serum concentrations of cytokines (pg/mL) are indicated on the y-axes, with IL-18 9545 T/G genotype indicated in the legend. Serum cytokine concentrations were measured 24 hours post-CPB. Patients homozygous for the T allele of the IL-18 9545 T/G SNP had significantly higher serum IL-18 and TNF-α concentrations and significantly lower serum IL-10 concentrations 24 hours post-CPB.