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Figure 1 | Critical Care

Figure 1

From: Novel polymorphism of interleukin-18 associated with greater inflammation after cardiac surgery

Figure 1

Haplotypes of the IL-18 gene. a) Haplotype diagram of the interleukin (IL)-18 gene. Haplotypes were inferred from unphased genotype data of 23 unrelated healthy Caucasians by the PHASE v2.0 program. Each column represents a polymorphic locus in the IL-18 gene, and is coded as either the common allele (black square) or the rare allele (white square). The position of each polymorphic locus relative to the start site of translation is indicated at the top of the diagram. Each row indicates a unique haplotype inferred from genotype data. The clustering of similar haplotypes into clades is done as per the phylogenetic relation among haplotypes given by the MEGA2 software package. The positions chosen for genotyping (-607, -137, 8148 and 9545) are indicated in the figure by bold numbering of the relative position and letter designations for the alleles within the diagram. b) Haplotype diagram of the interleukin-18 gene in the patient population under study. Haplotypes were inferred from unphased genotype data of 658 unrelated Caucasians making up the study cohort using the PHASE v2.0 program. Allele and clade designations within the diagram are as in Figure 1a. Haplotype frequency within the patient cohort is indicated to the right of each haplotype. Only haplotype clades with frequency greater than 5% are represented.

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