Table 1 Clinical and biochemical data of patients with alcoholic hepatitis and patients with resistant pruritus before albumin dialysis
Patients with severe alcoholic hepatitis n = 9 | Patients with resistant pruritus n = 4 | p = | |
|---|---|---|---|
Age (years) | 48.2 ± 2.0 | 52.0 ± 4.2 | n.s. |
Male/Female | 6/3 | 1/3 | |
Ascites | 7 | 0 | |
Encephalopathy | 5 | 0 | |
NCT (minute) | 3.68 ± 0.97 (5) | 1.01 ± 0.09 | 0.05 |
Bilirubin (mg/dl) | 22.8 ± 2.8 | 1.08 ± 0.05 | 0.005 |
AST (u/L) | 96 ± 11 | 52 ± 7 | 0.031 |
ALT (u/L) | 48 ± 4 | 93 ± 40 | n.s. |
AP (u/L) | 398 ± 53 | 999 ± 544 | 0.031 |
γGT (u/L) | 202 ± 65 | 449 ± 426 | n.s. |
Albumin (g/L) | 24.4 ± 1.03 | 36.5 ± 1.2 | 0.005 |
Prothrombin index (%) | 33.2 ± 2.8 | 91.5 ± 8.5 | 0.005 |
Creatinine | 1.7 ± 0.8 | 0.8 ± 0.1 | n.s. |
Serum Na | 130 ± 3 | 138 ± 2 | 0.01 |
Serum K | 3.5 ± 0.1 | 3.9 ± 0.2 | 0.03 |
Haemoglobin (g/L) | 10.5 ± 0.5 | 11.8 ± 1.1 | n.s. |
Leucocytes (cell/×109) | 12.9 ± 2.4 | 8.6 ± 3.7 | n.s. |
Platelets (cell/×109) | 105 ± 14 | 264 ± 51 | 0.005 |
Total amino acids (μM/L) | 2692 ± 274 | 1850 ± 93 | 0.01 |
Branched chain AA (μM/L) | 253 ± 37 | 331 ± 20 | n.s. |
Phenolic aromatic AA (μM/L) | 186 ± 26 | 111 ± 8 | 0.04 |
Fischer index | 1.32 ± 0.15 | 3.01 ± 0.12 | 0.005 |
Tryptophan (μM/L) | 28.2 ± 2.8 | 39.7 ± 2.7 | 0.02 |
Ammonium (μM/L) | 45.2 ± 11.6 | 23.2 ± 4.7 | n.s. |