Skip to main content

Table 2 Arterial blood gas analysis in BALB/c mice.

From: Mechanical ventilation using non-injurious ventilation settings causes lung injury in the absence of pre-existing lung injury in healthy mice

 

Control

Low VT

High VT

  

NaCl

NaHCO3

NaCl

NaHCO3

PH

7.34 (0.05)

7.22 (0.04)*

7.42 (0.05)

7.11 (0.07)‡

7.37 (0.08)

PaCO2 (mmHg)

39.3

(31.6 to 51.3)

35.7

(31.1 to 39.5)

41.2

(35.3 to 43.6)

40.8

(37.0 to 55.6)

44.3

(36.1 to 51.7)

PaO2 (mmHg)

 

193 (36)

168 (48)

173 (51)

161 (50)

HCO3- (mmol/l)

21.1

(17.9 to 24.1)

14.4

(12.9 to 15.2)

25.2

(23.6 to 25.9)

13.5

(12.1 to 14.7)

24.5

(22.7 to 25.4)

BE

-3.9

(-6.2 to -2.5)

-12.3

(-13.6 to -11.8)

0.15

(-1.1 to 2.2)

-15.9

(-16.7 to -14.8)

-0.7

(-2.4 to -0.1)

  1. Data are mean (SD) or median (IQR); Control = spontaneously breathing mice; Low VT = mice ventilated for five hours with a VT of 7.5 ml/kg; High VT = mice ventilated for five hours with a VT of 15 ml/kg. n = 6 per group. ‡p < 0.001 vs. control mice. PaCO2 = partical pressure of arterial carbon dioxide; PaO2 = partical pressure of arterial oxygen; BE = base excess.