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Figure 3 | Critical Care

Figure 3

From: Mechanical ventilation using non-injurious ventilation settings causes lung injury in the absence of pre-existing lung injury in healthy mice

Figure 3

Pulmonary levels of tumour necrosis factor (TNF)-α, interleukin (IL)-6, keratincyte-derived cytokine (KC) and macrophage inflammatory protein (MIP)-2 in lung tissue homogenate. Pulmonary levels of TNF-α, IL-6, KC and MIP-2 and in lung tissue homogenate in control mice, and in mice ventilated with low tidal volumes (LVT) and high VT (HVT) for five hours. Two fluid strategies (normal saline (white boxes) and sodium bicarbonate (grey boxes)) were compared. Data represent median and interquartile range of six mice. *p < 0.05 (LVT vs. control or sodium bicarbonate vs. saline, IL-6 and MIP-2 in C57Bl/6 mice); †p < 0.01 (HVT vs. LVT or LVT vs. control); ‡p < 0.001 (HVT vs. LVT or LVT vs. control).

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Critical Care

ISSN: 1364-8535