Epinephrine is more effective than other sympathomimetics in correcting cerebral hypoperfusion associated with mesenteric ischemic reperfusion insult

Table 1

% change	DOBUTAMINE			DOPAMINE			EPINEPHRINE
Rate	10	20	40	10	20	40	1	2	4
CO^**	28± 2^*	49± 13	44± 13	24± 7^*	41± 12	51± 20	29± 12^*	42± 12	39± 12
BP	-3± 6	-0.2± 5	-2.5± 8	0.4± 3	2± 3	1.5± 4	12± 6^§	25± 5^§	44± 7^§
CBF	-5± 6	10± 7	18± 9	-3± 4	5± 6	-2± 10	7± 12	26± 8	19± 7
CBF ext	9± 11	3± 7	1± 6	-1± 6	-2± 7	9± 7	-11± 6	-23± 6 ^§	-30± 8^§

^*:10 ≠ 20,40 or 1 ≠ 2,4,^**:SYMP ≠ CONT, ^§:EPI ≠ CONT,DOB,DP; P<0.05; RM Anova. All SYMP similarly improved cardiac output. EPI was the only one to increase BP and improve cerebral blood flow. The interruption of all SYMP resulted in a large drop in CBF (27± 5%) and BP (28± 3%) while CO remained unchanged.

ISSN: 1364-8535