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Table 4 Performance for sequential SOFA.

From: Evaluation of SOFA-based models for predicting mortality in the ICU: A systematic review

Max SOFA AUC Brier H/C-statistics Comp. AUC H/C-statistics Mort.
Pettilä et al (2002) [17], 5 days 0.792    LODS 0.827   H
     MODS 0.795   H
Junger et al (2002) [18], ICU stay 0.922       I
Bota et al (2002) [16], 24 hrs period 0.898    MODS 0.9   U
Ferreira et al (2001) [19], ICU stay 0.9       I
Total Max SOFA AUC Brier H/C-statistics Comp AUC H/C-statistics Mort.
Ho et al (2007) [11], ICU stay 0.829 0.1 C = 7.4 p = 0.496     H
Zygun et al (2005) [14], ICU stay 0.7   U = 9.2 p = 0.33 MODS 0.65 8.07 p = 0.43 H
Pettilä et al (2002) [17], ICU stay 0.816    LODS 0.839   H
     MODS 0.817   H
Zygun et al (2005) [14], ICU stay 0.69   U = 7.30 p = 0.50 MODS 0.64 9.09 p = 0.33 I
Kajdacsy-Balla Amaral et al (2005) [7], ICU stay 0.84   H: p = 0.95 C: p = 0.54     I
Junger et al (2002) [18], ICU stay 0.921       I
Moreno et al (1999) [21], ICU stay 0.847       I
Janssens et al (2000) [20], ICU stay 0.86       H
Delta SOFA AUC Brier H/C-statistics Comp AUC H/C-statistics Mort.
Ho et al (2007) [11], TMS – Adm 0.635 0.12 C = 20.2 p = 0.001     H
Zygun et al (2005) [14], TMS – Adm 0.54   U = 53.48 p < 0.01 MODS 0.55 31.2 p < 0.01 H
Pettilä et al (2002) [17], day 5 – Adm 0.6    LODS 0.633   H
     MODS 0.653   H
Zygun et al (2005) [14], TMS – Adm 0.51   U = 98.01 p < 0.01 MODS 0.52 70.52 p < 0.01 I
Junger et al (2002) [18], TMS – Adm 0.828       I
Moreno et al (1999) [21], TMS – Adm 0.742       I
Ferreira et al (2001) [19], 48 hrs – Adm 0.69       I
Ferreira et al (2001) [19], 96 hrs – Adm 0.62       I
Janssens et al (2000) [20], TMS – Adm 0.62       H
Mean SOFA AUC Brier H/C-statistics Comp AUC H/C-statistics Mort.
Zygun et al (2005) [14], ICU stay 0.77   U = 22.66 p < 0.01 MODS 0.74 46.13 p < 0.01 H
Zygun et al (2005) [14], ICU stay 0.79   U = 28.92 p < 0.01 MODS 0.75 42.72 p < 0.01 I
Ferreira et al (2001) [19], ICU stay 0.88       I
Total SOFA AUC Brier H/C-statistics Comp AUC H/C-statistics Mort.
Ferreira et al (2001) [19], ICU stay 0.85       I
Modified SOFA AUC Brier H/C-statistics Comp AUC H/C-statistics Mort.
Timsit et al (2002) [15], Adm 0.729   U = 11 p = 0.2 LODS 0.733 11.3 p = 0.19 H
Timsit et al (2002) [15], day 2 0.752   U = 8.3 p = 0.4 LODS 0.748   H
Timsit et al (2002) [15], day 3 0.773   U = 11.3 p = 0.19 LODS 0.761   H
Timsit et al (2002) [15], day 4 0.779   U = 7.3 p = 0.5 LODS 0.76   H
Timsit et al (2002) [15], day 5 0.763   U = 14.4 p = 0.07 LODS 0.749   H
Timsit et al (2002) [15], day 6 0.784   U = 11 p = 0.17 LODS 0.79   H
Timsit et al (2002) [15], day 7 0.768   U = 6.3 p = 0.62 LODS 0.746   H
Junger et al (2002) [18], Adm 0.799       I
  1. Adm = admission, AUC = Area Under the Receiver Operating Characteristic Curve, Comp. = Compared with, H = Hospital, H/C = H- or C- Hosmer-Lemeshow statistics, hrs = hours, I = ICU = Intensive care unit, LODS = Logistic Organ Dysfunction System, max = maximum, MODS = Multiple Organ Dysfunction Score, Mort. = Mortality, SOFA = Sequential Organ Failure Assessment, TMS = total max SOFA (always measured over entire ICU stay), U = Unspecified (mortality type or H/C statistic).