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Table 1 Study characteristics.

From: Evaluation of SOFA-based models for predicting mortality in the ICU: A systematic review

  Study design Population Models Variables Comparison  
  Setting (Location)a Study periodb Nc/ICU Typed/Mortality%e Model/Valid.f SOFA Abstractionsg Othersh Standard Modeli Mort.j
Toma et al (2008) [9] 1 ICU (NL) Jul 98 to Aug 05 2928/Mix/H = 24 LR/Ind. Seq of IOF1 SAPS II SAPS II H
Toma et al (2007) [8] 1 ICU (NL) Jul 98 to Aug 05 6276/Mix/H = 11 LR/Ind. Seq of SOFA2 SAPS II SAPS II H
Ho (2007) [4] 1 multidisc ICU (AU) Jan 05 to Dec 05 1311/Mix/H = 14.5 LR/Ind. TMS Adm Delta (TMS-Adm) APACHE II APACHE II H
Ho et al (2007) [11] 1 multidisc ICU (AU) Jan 05 to Dec 05 1311/Mix/H = 14.5 No TMS Adm Delta (TMS-Adm) No APACHE II, APS, RPH H
Holtfreter et al (2006) [12] 1 ICU (DE) 42 months 933/Mix/H = 25/I = 23.9 No Adm No 16 variables, APACHE II H
Zygun et al (2005) [14] 3 ICUs (CA) May 00 to Apr 01 1436/Mix/H = 35.1/I = 27 LR/NR Adm TMS, Mean (ICU stay), Delta (TMS-Adm), Adm (i) No MODS H/I
Cabré et al (2005) [6] 79 ICUs (75 ES, 4 L-Am) Feb 01 to Mar 01 1324/Mix/H = 44.6/I = 37.3 LR/NR Min (MODS period), Max (MODS period), 5-day trend3 Age No H
Timsit et al (2002) [15] 6 ICUs (FR) 24 months 1685/Mix/H = 30.3/I = 22.5 LR/Ind.* D1-7, D1-7 (mod) No LODS H
Pettilä et al (2002) [17] 1 med-surg ICU (FI) NR 520/Mix/H = 30/I = 16.5 No Adm, D5, Max (5d), Delta (d5-d1), TMS No APACHE III, MODS, LODS H
Janssens et al (2000) [20] 1 med ICU (DE) Nov 97 to Feb 98 303/Med/H = 14.5/I = 6.3 LR/NR Adm, TMS, Delta (TMS-Adm) No No H
Khwannimit (2007) [10] 1 ICU (TH) Jul 04 to Mar 06 1782/Mix/H = 22/I = 16.4 No Adm No MODS, SOFA, LODS I
Rivera- Fernández et al (2007) [5] 55 ICUs (EU) 2 months in 97/98 6409/Mix/H = 20.6/I = 13.9 LR/Ind. Mean (ICU stay), Max(ICU stay) SAPS II, diagnosis events SAPS II I
Gosling et al (2006) [13] 1 general ICU (UK) Nov 02 to Oct 03 431/Mix/I = 20.9 No Adm SOFA No APACHE II, urine albumin and 5 other factors I
Kajdacsy- Balla Amaral et al (2005) [7] 40 ICUs (1 AU, 35 EU, 1 N-Am, 3 S-Am) 1 May 95 to 31 May 95 748 (6 countries)/Mix/I = 21.5 LR/NR Adm, TMS, Delta (48 h-Adm), Delta (TMS-Adm) Different parameters No I
Junger et al (2002) [18] 1 operative ICU (DE) Apr 99 to Mar 00 524/Surg/I = 12.4 No Max (ICU stay), TMS, Delta (TMS-Adm), Adm (mod) No No I
Ferreira et al (2001) [19] 1 med-surg ICU (BE) Apr 99 to Jul 99 352/Mix/I = 23 No Adm, 48 h, 96 h, Delta (48 h-Adm), Delta (96 h-Adm), Max (ICU stay), Mean (ICU stay), Total No No I
Moreno et al (1999) [21] 40 ICUs (1 AU, 35 EU, 1 N-Am, 3 S-Am) May 95 1449/Mix/H = 26/I = 22 LR/NR Adm, TMS, Delta (TMS-Adm), Adm (i) No No I
Bota et al (2002) [16] 1 ICU (BE) Apr to Jul99, Oct to Nov99, Jul to Sep00 949/Mix/U = 29.1 No Adm, 48 h, 96 h, Dis, Max (24 h), Adm (c), 48 h (c), 96 h (c), Dis (c), Max (c, 24 h) No APACHE II, MODS U
  1. a: AU = Australia, BE = Belgium, CA = Canada, DE = Germany, EU = European Union, ES = Spain, FR = France, FI = Finland, ICU = Intensive Care Unit, L-Am = Latin-America, med = medical, multidisc = multidisciplinary, N-Am = North-America, NL = The Netherlands, S-Am = South-America, surg = surgical, TH = Thailand, UK = United Kingdom.
  2. b: NR = Not reported.
  3. c: N = Number of patients.
  4. d: Med = medical, Mix = Mixed, Surg = surgical.
  5. e: H = Hospital mortality, I = ICU mortality, U = Unspecified mortality.
  6. f: Ind. = Independent validation set used (*indicates the use of bootstrapping), LR = Logistic Regression, Model = Model type reported, No = No model was used, NR = Not Reported, Valid. = Validation method.
  7. g: 1 = Sequences of categorised individual components of SOFA (Failure-Non failure), 2 = Sequences of categorised SOFA scores (High-Medium-Low), 3 = SOFA trend over 5 days (-1 if SOFA is decreased, 0 if SOFA is unchanged, 1 if SOFA is increased), Adm = Admission, c = cardiovascular component of SOFA, cust = customised, Dis = Discharge, Dx = Day x (x = day number), i = individual components of SOFA, IOF = individual Organ Failure scores, Max = Maximum, mod = modified, seq = sequences, SOFA = Sequential Organ Failure Assessment, TMS = Total Maximum SOFA, xd = x days (x = number of days), xh = x hours (x = number of hours).
  8. h: APACHE = Acute Physiology And Chronic Health Evaluation, SAPS = Simplified Acute Physiology Score.
  9. i: APACHE = Acute Physiology And Chronic Health Evaluation, APS = Acute Physiology Score, LODS = Logistic Organ Dysfunction System, MODS = Multiple Organ Dysfunction Score, RPH = Royal Perth Hospital Intensive Care Unit, SAPS = Simplified Acute Physiology Score, SOFA = Sequential Organ Failure Assessment.
  10. j: H = Hospital mortality, I = ICU mortality, Mort. = Mortality, U = Unspecified mortality.