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Figure 3 | Critical Care

Figure 3

From: Phosphodiesterase 4 inhibition but not beta-adrenergic stimulation suppresses tumor necrosis factor-alpha release in peripheral blood mononuclear cells in septic shock

Figure 3

Suppression of lipopolysaccharide (LPS)-mediated or Staphylococcus aureus enterotoxin B (SEB)-mediated tumor necrosis factor-alpha (TNF-α) expression in CD14+ monocytes of healthy volunteers. Suppression of LPS-mediated (100 ng/mL) (a) or SEB-mediated (10 ng/mL) (b) TNF-α expression in CD14+ monocytes of healthy volunteers (n = 20) in a concentration-dependent manner by isoprenaline, rolipram, and forskolin (all 0.001 to 10 μmol/L) is shown. TNF-α expression was measured by flow cytometry, and histograms of median fluorescence intensity (MFI) and averages with standard error of the mean from all probands are shown. FITC, fluorescein isothiocyanate.

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Critical Care

ISSN: 1364-8535