Table 1 Demographic and clinical characteristics of the 311 patients at the time of diagnosis of the first episode of severe sepsis. See definitions in the text and list of abbreviations for meaning

Median

IQR

Age (years)

68

54.9 to 74.5

No.

%

Sex (male)

208

66.9

61.3 to 72.1

McCabe score:

   0

81

26

21.2 to 31.2

   1

131

42.1

36.5 to 47.8

   2

63

20.3

15.9 to 25.1

   3

36

11.6

8.2 to 15.7

Category:

   Medical

179

57.6

51.9 to 63.1

   Urgent surgery

93

29.9

24.9 to 35.3

   Scheduled surgery

23

7.4

4.7 to 10.9

   Traumatological

16

5.1

3.0 to 8.2

Origin:

   Medical and Surgical ward

167

53.7

48.0 to 59.0

   Emergency department

67

21.5

12.5 to 21.0

   Operating room

51

16.4

17.1 to 26.5

   Other

26

8.3

5.5 to 12.0

Comorbidities:

   Chronic respiratory failure

46

14.8

11.0 to 19.2

   Immunodeficiency

41

13.2

9.6 to 17.5

   Risk of bleeding

31

10

6.9 to 13.8

   Chronic alcoholism

25

8

5.3 to 11.6

   Chronic renal failure

23

7.4

4.7 to 10.9

   IDDM

22

7.1

4.5 to 10.5

   Metastatic cancer

17

5.5

3.2 to 8.6

   Chronic heart failure

15

4.8

2.7 to 7.8

   Chronic liver failure

14

4.5

2.5 to 7.4

   AIDS

4

1.3

0.4 to 3.3

No. of comorbidities:

   None

140

45

39.4 to 50.7

   One

114

36.7

31.3 to 42.3

   Two

46

14.8

11.0 to 19.2

   Three or more

11

3.5

1.8 to 6.2

Organ failure:

   Respiratory

233

74.9

69.7 to 79.6

   Shock

180

57.9

52.1 to 63.4

   Cardiovascular

158

50.8

45.1 to 56.5

   Renal

124

39.9

34.4 to 45.6

   Haematological

69

22.2

17.7 to 27.2

   Liver

40

12.9

9.3 to 17.1

   Neurological

37

11.9

8.5 to 16.0

No. of organ failures:

   One

68

21.9

17.4 to 26.9

   Two

86

27.7

22.8 to 32.0

   Three

81

26

21.3 to 31.3

   Four

39

12.5

9.1 to 16.7

   Five or more

37

11.9

6.6 to 16.0

Median

Mean (SD)

APACHE II score (D1)

25

25.5 (± 7.1)

24.5 to 26.2

LODS score (D0)

6

6.3 (± 3.6)

5.9 to 6.7

SOFA score (D1)

10

9.6 (± 3.7)

9.2 to 10.0