Table 1 Clinical studies of Ang-1, Ang-2 and soluble Tie2 in critically ill patients
From: Bench-to-bedside review: Angiopoietin signalling in critical illness – a future target?
Study | Patients | Ang-1 | Ang-2 | Soluble Tie2 | Clinical effects |
|---|---|---|---|---|---|
Lee et al. [33] | ACS: 82 AMI, 44 unstable angina, 40 stable CAD 40 HCs | NS | Higher in AMI versus HCs, SA, unstable angina | Higher in AMI versus HCs, SA, unstable angina | ND |
Kugathasan et al. [23] | PAH: 6 idiopathic, 7 with other disease 8 HCs | NS | NS | Tie2 mRNA higher in lung of PAH patients versus HCs | ND |
Parikh et al. [28] | ICU patients: 17 severe sepsis, 5 mild sepsis 29 HCs | NS | Higher in severe sepsis versus HCs | ND | Ang-2 levels correlate with low PaO2/FiO2 |
Gallagher et al. [180] | Vascular leakage: 14 IL-2, 14 IL-2+bevacizumab | ND | Higher during therapy | ND | Ang-2 levels rise on days of IL-2 therapy; high levels on day 3 predict vascular leakage (stop therapy) |
Gallagher et al. [29] | ARDS: 45 ICU, 18 ARDS | ND | Higher in ARDS versus ICU patients; in ARDS, higher in nonsurvivors | ND | High levels of Ang-2 on day patient meets ARDS criteria. Ang-2 levels in ARDS patients correlate with mortality |
Giuliano et al. [35] | Septic shock children: 20 SIRS 20 sepsis, 61 septic shock 15 HCs | Ang-1 lower in septic shock versus sepsis and SIRS | Higher in septic shock versus HCs, SIRS and sepsis | ND | ND |
Orfanos et al. [37] | ICU patients: 6 no SIRS, 8 SIRS, 16 sepsis, 18 severe sepsis, 13 septic shock | ND | Higher in severe sepsis versus no SIRS and sepsis | ND | Ang-2 levels related to severe sepsis and TNF-α levels |
Scholz et al. [181] | 180 liver cirrhosis patients 40 HCs | ND | Higher in cirrhosis versus HCs | ND | ND |
Ganter et al. [34] | 208 trauma patients in ER | Unchanged | Higher within 30 minutes after ER admission | ND | Ang-2 levels correlate with met ISS and mortality. Ang-2 higher in nonsurvivors |
van der Heijden et al. [39] | 24 sepsis, 88 nonseptic critically ill 15 HCs | Ang-1 lower in sepsis and critical illness versus HCs | Higher in critically ill patients; higher in septic than nonseptic patients | ND | Ang-2 levels associated with pulmonary permeability oedema and severity of ALI in septic and nonseptic critically ill patients |
Lukasz et al. [36] | 94 critically ill medical ICU patients 30 HCs | Ang-1 correlated negatively with SOFA Score | Ang-2 correlates positively with SOFA Score | ND | Ang-1 correlates negatively and Ang-2 positively with SOFA score |
Siner et al. [38] | Critically ill patients: 20 nonseptic (ICU), 10 sepsis, 12 severe sepsis, 24 septic shock | ND | Ang-2 increases with severity of sepsis | ND | Increase in Ang-2 associated with severity of illness and hospital mortality |