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Table 6 SMART: Hosmer-Lemeshow goodness-of-fit test results for prediction of shock and organ failure and survival in severe sepsis from baseline plus serial data

From: Prospectively validated predictions of shock and organ failure in individual septic surgical patients: the Systemic Mediator Associated Response Test

  Day
Independent variable 1 2 3 4 5 6 7 14 21 28
Chest radiography score* - - - - - - - - - -
Mechanical ventilation - - - 3.5003 11.159 3.5366 4.7716 16.473 14.65 3.8411
     (NS) (0.0836) (0.1706) (0.6878) (0.0001) (0.048) (0.8712)
ARDS - 50.182 5.1079 229.18 6.7868 7.4788 162.02 20.147 13.294 5.5629
   (0.0001) (NS) (0.0001) (0.079) (0.2788) (0.0001) (0.0026) (0.0099) (0.5916)
DIC - 6.061 2.513 2.1413 179.27 4.8029 2.4973 8.0683 245.38 -
   (0.7338) (0.4261) (0.9764) (0.0001) (0.6840) (NS) (NS) (0.0001)  
Hepatobiliary failure - 4969 42.872 11.154 19.672 25.623 40.83 23.322 3.1979 9.207
   (0.0001) (0.0001) (0.1321) (0.201) (0.0003) (0.0001) (0.0015) (0.959) (0.3251)
Renal insufficiency - 0.8232 3297.6 1.4857 20.514 2172 14.25 20.981 12.247 8.1239
   (NS) (0.0001) (0.9604) (0.0086) (0.0001) (0.0759) (0.0072) (0.0927) (0.0044)
Shock - 14.611 89.307 11.089 20.737 74.51 38.134 62.76 14.042 -
   (0.0413) (0.0001) (0.1348) (0.0020) (0.0001) (0.0001) (0.0001) (0.0001)  
Survival status - 10.315 15.226 8.8376 13.146 13.146 11.177 13.851 5.54 7.3106
   (0.2436) (0.0849) (0.2645) (0.0686) (0.0686) (0.2688) (0.5835) (0.5944) (0.5835)
GCS score < 11 - 1064.3 105.34 729.5 5418 33.064 16.397 16.07 4.2473 0.8312
   (0.0001) (0.0001) (0.0001) (0.0001) (0.0001) (0.0217) (0.0654) (0.9355) (NS)
  1. Values are Hosmer-Lemeshow goodness-of-fit test statistics (P values). *Chest radiography score = 0-4 quadrants pulmonary edema. Organ failure and shock definitions were from Fisher et al [18]. GCS Glascow Coma Scale; NS, not significant.