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Table 1 Baseline characteristics of the patients

From: Norepinephrine weaning in septic shock patients by closed loop control based on fuzzy logic

Variable

Control group (n = 20)

Fuzzy group (n = 19)

Age (years)

66 ± 12

64 ± 12

Male sex

70%

58%

Weight (kg)

67 ± 15

71 ± 14

Prior or coexisting conditions

  

   Chronic obstructive pulmonary disease

40%

37%

   Congestive cardiomyopathy

0%

5%

   Diabetes

10%

5%

   Liver disease

2%

0%

   Chronic renal failure

0%

0%

   Cancer

30%

26%

Activity limitation (A/B/C/D)a

3/8/7/2

4/10/5/0

McCabe classification (1/2/3)b

10/6/4

12/4/3

Recent surgical history

20%

16%

Disease severity

  

   Temperature (°C)

36.8 ± 1.8

37.7 ± 1.5

   Heart rate (beats/minute)

119 ± 26

103 ± 27

   Systolic blood pressure (mmHg)

84 ± 14

80 ± 22

   Mean blood pressure (mmHg)

61 ± 12

59 ± 16

   White cell count (/mm3)

16,100 ± 8,800

17,600 ± 12,000

   Platelet (× 103/μl)

263 ± 198

262 ± 138

   Haematocrit (%)

30 ± 7

32 ± 6

   Blood urea nitrogen (mmol/l)

10.3 ± 6.3

10.4 ± 6.2

   Creatinine (μmol/l)

113 ± 70

136 ± 88

   Total bilirubin (μmol/l)

12.3

15.5

   Lactate (mmol/l)

2.5 ± 2.1

2.0 ± 0.8

   PaO2/FiO2 (mmHg)

166 ± 81

181 ± 93

   Arterial pH

7.28 ± 0.14

7.31 ± 0.09

   SAPS II scale

62 ± 23

58 ± 16

   Initial SOFA score

11.0 ± 2.5

11.2 ± 3.3

Norepinephrine infusion at the time of randomization (μg/kg per minute)

0.6 ± 0.4

0.8 ± 0.4

Site of infectionc

  

   Lung

75%

63%

   Abdomen

25%

10%

   Urinary tract

5%

15%

   Other

5%

10%

Bacterial pathogen staining

  

   Gram-negative

40%

58%

   Gram-positive

25%

10%

   Unconfirmed

35%

32%

  1. Values are expressed as number, percentage or mean ± standard deviation. Percentages may not total 100 because of rounding. aLevels of activity were defined as follows (Knaus Chronic Health Status score): A = prior good health, no functional limitations; B = mild to moderate limitation of activity because of a chronic medical problem; C = chronic disease producing serious but not incapacitating limitation of activity; and D = severe restriction of activity due to disease, includes persons bedridden or institutionalized due to illness. bMcCabe classification: 1 = nonfatal disease; 2 = ultimately fatal disease; and 3 = rapidly fatal disease. cThe site of infection was either documented or presumed on the basis of clinical findings. PaO2/FiO2, arterial oxygen tension/fractional inspuired oxygen ratio; SAPS, Simplified Acute Physiology Score; SOFA, Sequential Organ Failure Assessment.