From: Norepinephrine weaning in septic shock patients by closed loop control based on fuzzy logic
Variable | Control group (n = 20) | Fuzzy group (n = 19) |
---|---|---|
Age (years) | 66 ± 12 | 64 ± 12 |
Male sex | 70% | 58% |
Weight (kg) | 67 ± 15 | 71 ± 14 |
Prior or coexisting conditions | ||
Chronic obstructive pulmonary disease | 40% | 37% |
Congestive cardiomyopathy | 0% | 5% |
Diabetes | 10% | 5% |
Liver disease | 2% | 0% |
Chronic renal failure | 0% | 0% |
Cancer | 30% | 26% |
Activity limitation (A/B/C/D)a | 3/8/7/2 | 4/10/5/0 |
McCabe classification (1/2/3)b | 10/6/4 | 12/4/3 |
Recent surgical history | 20% | 16% |
Disease severity | ||
Temperature (°C) | 36.8 ± 1.8 | 37.7 ± 1.5 |
Heart rate (beats/minute) | 119 ± 26 | 103 ± 27 |
Systolic blood pressure (mmHg) | 84 ± 14 | 80 ± 22 |
Mean blood pressure (mmHg) | 61 ± 12 | 59 ± 16 |
White cell count (/mm3) | 16,100 ± 8,800 | 17,600 ± 12,000 |
Platelet (× 103/μl) | 263 ± 198 | 262 ± 138 |
Haematocrit (%) | 30 ± 7 | 32 ± 6 |
Blood urea nitrogen (mmol/l) | 10.3 ± 6.3 | 10.4 ± 6.2 |
Creatinine (μmol/l) | 113 ± 70 | 136 ± 88 |
Total bilirubin (μmol/l) | 12.3 | 15.5 |
Lactate (mmol/l) | 2.5 ± 2.1 | 2.0 ± 0.8 |
PaO2/FiO2 (mmHg) | 166 ± 81 | 181 ± 93 |
Arterial pH | 7.28 ± 0.14 | 7.31 ± 0.09 |
SAPS II scale | 62 ± 23 | 58 ± 16 |
Initial SOFA score | 11.0 ± 2.5 | 11.2 ± 3.3 |
Norepinephrine infusion at the time of randomization (μg/kg per minute) | 0.6 ± 0.4 | 0.8 ± 0.4 |
Site of infectionc | ||
Lung | 75% | 63% |
Abdomen | 25% | 10% |
Urinary tract | 5% | 15% |
Other | 5% | 10% |
Bacterial pathogen staining | ||
Gram-negative | 40% | 58% |
Gram-positive | 25% | 10% |
Unconfirmed | 35% | 32% |