Skip to main content

Table 2 Effects of recombinant human activated protein C on oleic acid-induced changes in oxygen-related variables and body temperature in awake sheep

From: Recombinant human activated protein C ameliorates oleic acid-induced lung injury in awake sheep

 

Time

 

0 hours

2 hours

SaO2, percentage

  

   Sham

99 ± 0

99 ± 0

   OA

98 ± 1

88 ± 5a

   OA+rhAPC

99 ± 1

97 ± 1

AaPO2, mm Hg

  

   Sham

29 ± 8

27 ± 7

   OA

33 ± 8

54 ± 10a

   OA+rhAPC

28 ± 13

34 ± 12b

DO2, mL/min per m2

  

   Sham

818 ± 78

705 ± 53

   OA

825 ± 39

600 ± 56a

   OA+rhAPC

805 ± 71

566 ± 31a

VO2, mL/min per m2

  

   Sham

334 ± 38

258 ± 41

   OA

316 ± 34

278 ± 110

   OA+rhAPC

316 ± 75

214 ± 51a

O2ER, percentage

  

   Sham

38 ± 5

34 ± 3

   OA

38 ± 2

47 ± 4

   OA+rhAPC

40 ± 1

39 ± 2

PaCO2, kPa

  

   Sham

37 ± 2

35 ± 2

   OA

36 ± 1

41 ± 4

   OA+rhAPC

35 ± 1

40 ± 2

Qs/Qt

  

   Sham

0.042 ± 0.009

0.062 ± 0.018

   OA

0.062 ± 0.014

0.246 ± 0.080a

   OA+rhAPC

0.045 ± 0.016

0.087 ± 0.027

Arterial pH

  

   Sham

7.51 ± 0.02

7.52 ± 0.01

   OA

7.50 ± 0.01

7.44 ± 0.02

   OA+rhAPC

7.51 ± 0.01

7.50 ± 0.02

Hemoglobin, g/dL

  

   Sham

10 ± 1

10 ± 0

   OA

10 ± 0

11 ± 0

   OA+rhAPC

10 ± 0

10 ± 0

Body temperature, °C

  

   Sham

40.0 ± 0.2

39.5 ± 0.4

   OA

39.3 ± 0.3

39.3 ± 0.3

   OA+rhAPC

39.4 ± 0.1

39.3 ± 0.1

  1. Values are presented as mean ± standard error of the mean. Sham refers to the sham-operated sheep (n = 6), OA refers to sheep receiving infusion of oleic acid (n = 8), and OA+rhAPC refers to sheep receiving oleic acid and recombinant human activated protein C (n = 8). aP < 0.05 from t = 0 hours. bP < 0.05 between OA and the OA+rhAPC groups. AaPO2, alveolar-arterial oxygen tension difference; DO2, oxygen delivery index; O2ER, oxygen extraction ratio; PaCO2 arterial partial pressure of carbon dioxide; Qs/Qt, venous admixture; SaO2, arterial oxygen saturation; VO2, oxygen consumption index.