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Table 1 Effects of recombinant human activated protein C on oleic acid-induced changes in systemic and pulmonary hemodynamics in awake sheep

From: Recombinant human activated protein C ameliorates oleic acid-induced lung injury in awake sheep

 

Time

 

0 hours

1 hour

2 hours

MAP, mm Hg

   

   Sham

99 ± 4

99 ± 5

98 ± 5

   OA

94 ± 3

102 ± 2

104 ± 3†a

   OA+rhAPC

94 ± 3

99 ± 3

98 ± 4

CI, L/min per m2

   

   Sham

5.8 ± 0.2

5.5 ± 0.2

5.3 ± 0.2

   OA

6.3 ± 0.3

4.8 ± 0.4a

4.7 ± 0.5

   OA+rhAPC

5.8 ± 0.4

4.5 ± 0.3a

4.2 ± 0.3a

SVRI, dynessecm2/cm5

   

   Sham

1,627 ± 58

1,497 ± 97

1,479 ± 153

   OA

1,231 ± 65

1,870 ± 320

1,696 ± 130a

   OA+rhAPC

1,326 ± 69

1,734 ± 132a

2,085 ± 220a

PAOP, mm Hg

   

   Sham

9 ± 0

8 ± 0

9 ± 1

   OA

9 ± 0

13 ± 1a

13 ± 1a

   OA+rhAPC

8 ± 0

12 ± 1a

11 ± 1a

Pmo, mm Hg

   

   Sham

7 ± 0

7 ± 0

7 ± 0

   OA

7 ± 1

10 ± 1

12 ± 1a

   OA+rhAPC

7 ± 1

11 ± 1a

10 ± 1a

PVRI, dynessecm2/cm5

   

   Sham

112 ± 12

134 ± 15

136 ± 9

   OA

104 ± 8

333 ± 59a

300 ± 39a

   OA+rhAPC

132 ± 8b

233 ± 25a

231 ± 28a

HR, beats per minute

   

   Sham

104 ± 6

103 ± 6

93 ± 6

   OA

109 ± 5

106 ± 12

104 ± 12

   OA+rhAPC

99 ± 6

95 ± 8

84 ± 5a

SVI, mL/beat per m2

   

   Sham

58 ± 4

55 ± 2

60 ± 6

   OA

59 ± 5

48 ± 5

47 ± 6

   OA+rhAPC

58 ± 5

49 ± 4a

50 ± 4a

LVSWI, gm/m2

   

   Sham

70 ± 4

67 ± 3

71 ± 2

   OA

69 ± 8

57 ± 5

59 ± 8

   OA+rhAPC

68 ± 3

57 ± 4

59 ± 5

RVSWI, gm/m2

   

   Sham

11 ± 1

11 ± 0

12 ± 1

   OA

12 ± 1

17 ± 2a

15 ± 1

   OA+rhAPC

11 ± 1

15 ± 1

14 ± 1

  1. Values are presented as mean ± standard error of the mean. Sham refers to sham-operated sheep (n = 6), OA refers to sheep receiving infusion of oleic acid (n = 8), and OA+rhAPC refers to sheep receiving oleic acid and recombinant human activated protein C (n = 8). aP < 0.05 from t = 0 hours. bP < 0.05 between OA and the OA+rhAPC groups. CI, cardiac index; HR, heart rate; LVSWI, left ventricular stroke work index; MAP, mean arterial pressure; PAOP, pulmonary artery occlusion pressure; Pmo, pulmonary micro-occlusion pressure; PVRI, pulmonary vascular resistance index; RVSWI, right ventricular stroke work index; SVI, stroke volume index; SVRI, systemic vascular resistance index.