From: Recombinant human activated protein C ameliorates oleic acid-induced lung injury in awake sheep
 | Time | ||
---|---|---|---|
 | 0 hours | 1 hour | 2 hours |
MAP, mm Hg | Â | Â | Â |
   Sham | 99 ± 4 | 99 ± 5 | 98 ± 5 |
   OA | 94 ± 3 | 102 ± 2 | 104 ± 3†a |
   OA+rhAPC | 94 ± 3 | 99 ± 3 | 98 ± 4 |
CI, L/min per m2 | Â | Â | Â |
   Sham | 5.8 ± 0.2 | 5.5 ± 0.2 | 5.3 ± 0.2 |
   OA | 6.3 ± 0.3 | 4.8 ± 0.4a | 4.7 ± 0.5 |
   OA+rhAPC | 5.8 ± 0.4 | 4.5 ± 0.3a | 4.2 ± 0.3a |
SVRI, dynessecm2/cm5 | Â | Â | Â |
   Sham | 1,627 ± 58 | 1,497 ± 97 | 1,479 ± 153 |
   OA | 1,231 ± 65 | 1,870 ± 320 | 1,696 ± 130a |
   OA+rhAPC | 1,326 ± 69 | 1,734 ± 132a | 2,085 ± 220a |
PAOP, mm Hg | Â | Â | Â |
   Sham | 9 ± 0 | 8 ± 0 | 9 ± 1 |
   OA | 9 ± 0 | 13 ± 1a | 13 ± 1a |
   OA+rhAPC | 8 ± 0 | 12 ± 1a | 11 ± 1a |
Pmo, mm Hg | Â | Â | Â |
   Sham | 7 ± 0 | 7 ± 0 | 7 ± 0 |
   OA | 7 ± 1 | 10 ± 1 | 12 ± 1a |
   OA+rhAPC | 7 ± 1 | 11 ± 1a | 10 ± 1a |
PVRI, dynessecm2/cm5 | Â | Â | Â |
   Sham | 112 ± 12 | 134 ± 15 | 136 ± 9 |
   OA | 104 ± 8 | 333 ± 59a | 300 ± 39a |
   OA+rhAPC | 132 ± 8b | 233 ± 25a | 231 ± 28a |
HR, beats per minute | Â | Â | Â |
   Sham | 104 ± 6 | 103 ± 6 | 93 ± 6 |
   OA | 109 ± 5 | 106 ± 12 | 104 ± 12 |
   OA+rhAPC | 99 ± 6 | 95 ± 8 | 84 ± 5a |
SVI, mL/beat per m2 | Â | Â | Â |
   Sham | 58 ± 4 | 55 ± 2 | 60 ± 6 |
   OA | 59 ± 5 | 48 ± 5 | 47 ± 6 |
   OA+rhAPC | 58 ± 5 | 49 ± 4a | 50 ± 4a |
LVSWI, gm/m2 | Â | Â | Â |
   Sham | 70 ± 4 | 67 ± 3 | 71 ± 2 |
   OA | 69 ± 8 | 57 ± 5 | 59 ± 8 |
   OA+rhAPC | 68 ± 3 | 57 ± 4 | 59 ± 5 |
RVSWI, gm/m2 | Â | Â | Â |
   Sham | 11 ± 1 | 11 ± 0 | 12 ± 1 |
   OA | 12 ± 1 | 17 ± 2a | 15 ± 1 |
   OA+rhAPC | 11 ± 1 | 15 ± 1 | 14 ± 1 |