Figure 1

Changes in pulmonary artery pressure (PAP), right atrial pressure (RAP), and extravascular lung water index (EVLWI) in awake instrumented sheep subjected to intravenous bolus injection of oleic acid (OA) and co-administration of recombinant human activated protein C (rhAPC). In the figure, OA refers to the oleic acid-alone group (n = 8), OA+rhAPC refers to the rhAPC-treated OA group (n = 8), and sham refers to sham-operated animals (n = 6). Data are presented as mean ± standard error of the mean. *P < 0.05 between OA and OA+rhAPC groups; ^†P < 0.05 from t = 0 hours in the OA group; ^‡P < 0.05 from t = 0 hours in the OA+rhAPC group.