Cardiorespiratory effects of spontaneous breathing in two different models of experimental lung injury: a randomized controlled trial

Varelmann, Dirk; Muders, Thomas; Zinserling, Jörg; Guenther, Ulf; Magnusson, Anders; Hedenstierna, Göran; Putensen, Christian; Wrigge, Hermann

doi:10.1186/cc7108

Critical Care

Table 2 Oxygenation and hemodynamic parameters

From: Cardiorespiratory effects of spontaneous breathing in two different models of experimental lung injury: a randomized controlled trial

		SB	BL-ALI	Treatment	Lung injury	Time	Injury type	Mode	Inter-action
PaO₂/FiO₂, mm Hg	HCl	+	132 ± 18	150 ± 50	^a				TM^a
		-	151 ± 58	137 ± 104
	OA	+	145 ± 51	184 ± 116
		-	146 ± 68	109 ± 46
HR, beats per minute	HCl	+	96 ± 12	112 ± 11	^a	^a
		-	100 ± 22	108 ± 20
	OA	+	102 ± 11	110 ± 23
		-	112 ± 18	119 ± 23
MAP, mm Hg	HCl	+	79 ± 8	86 ± 9^b		^a	^a
		-	77 ± 23	92 ± 13^b
	OA	+	93 ± 12^d	97 ± 13^{b, d}
		-	101 ± 10^d	104 ± 15^{b, d}
CVP, mm Hg	HCl	+	11 ± 2	10 ± 2^b	^a
		-	12 ± 3	12 ± 2^b
	OA	+	15 ± 2^d	14 ± 2^{b, d}
		-	15 ± 4^d	14 ± 3^{b, d}
SVR, dyne-second/cm⁵	HCl	+	1,335 ± 198	1,057 ± 191^b	^a	^a	^a
		-	1,255 ± 429	1,072 ± 333^b
	OA	+	1,513 ± 344	1,281 ± 388^b
		-	1,490 ± 384	1,060 ± 206^b
CO, L/minute	HCl	+	4.1 ± 0.3	4.6 ± 0.8	^a			^a
		-	4.2 ± 0.9^c	4.8 ± 0.9^c
	OA	+	4.2 ± 0.7	4.3 ± 0.8
		-	4.8 ± 0.8^c	5.5 ± 0.7^c
DO₂, mL/minute	HCl	+	323 ± 28	393 ± 71	^a	^a
		-	336 ± 63	369 ± 89
	OA	+	335 ± 89	360 ± 48
		-	408 ± 80	430 ± 118
VO₂, mL/minute	HCl	+	181 ± 31	172 ± 33	^a		^a
		-	169 ± 23	172 ± 32
	OA	+	159 ± 27^c	147 ± 34^c
		-	154 ± 32^c	167 ± 42^c
Shunt ${\dot{V}}_{A} / \dot{Q}$ < 0.005, %Q_T	HCl	+	27.1 ± 6.2	23.3 ± 12.7		^a			TM^a
		-	27.7 ± 7.9	37.4 ± 17.4^b
	OA	+	32.6 ± 18.9	26.0 ± 17.9
		-	32.4 ± 12.4	47.2 ± 17.1^b
Dead space ${\dot{V}}_{A} / \dot{Q}$ > 100, %Ve	HCl	+	33.0 ± 5.5	45.1 ± 11.8		^a
		-	34.4 ± 5.9	38.7 ± 3.9
	OA	+	39.1 ± 6.6	44.9 ± 12.8
		-	39.0 ± 6.0	46.2 ± 12.2

Pre-acute lung injury (ALI) (Table S1 in additional data file) was tested only against baseline ALI (BL-ALI). Post hoc testing was always performed if a significant F ratio for a factor or the interaction of factors was obtained by repeated measures analysis of variance (^aP < 0.05), but only significant differences are marked: ^bP < 0.05 for within-group differences (BL-ALI versus Treatment), ^cP < 0.05 for between-group differences (HCl-ALI versus OA-ALI), and ^dP < 0.05 for between-group differences (PCV + SB versus PCV – SB) (post hoc Tukey multiple comparison test). +, pressure-controlled ventilation with maintained spontaneous breathing; -, pressure-controlled ventilation without spontaneous breathing; CO, cardiac output; CVP, central venous pressure; DO₂, oxygen delivery; HCl, hydrochloric acid-induced acute lung injury; HCl-ALI, hydrochloric acid-induced acute lung injury; HR, heart rate; M, mode; MAP, mean arterial pressure; OA, oleic acid-induced acute lung injury; OA-ALI, oleic acid-induced acute lung injury; PaO₂/FiO₂, arterial partial pressure of oxygen/inspiratory fraction of oxygen; PCV + SB, pressure-controlled ventilation with spontaneous breathing; PCV – SB, pressure-controlled ventilation without spontaneous breathing; %Q_T, percentage of cardiac output; SB, spontaneous breathing; SVR, systemic vascular resistance; T, time; ${\dot{V}}_{A} / \dot{Q}$ , ventilation/perfusion (ratio); %Ve, percentage of minute ventilation; VO₂, oxygen consumption.

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