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Table 1 Ventilation and respiratory system mechanics

From: Cardiorespiratory effects of spontaneous breathing in two different models of experimental lung injury: a randomized controlled trial

  

SB

Baseline ALI

Treatment

Lung injury

Time

Injury type

Mode

Inter-action

RR, breaths per minute

HCl

+

28.2 ± 3.4

45.3 ± 8.5b

a

a

 

a

 
  

-

28.4 ± 2.8

28.3 ± 3.2c

     
 

OA

+

29.2 ± 0.1

43.5 ± 6.7b

     
  

-

29.1 ± 1.8

29.2 ± 1.7c

     

VT, mL

HCl

+

326 ± 46

212 ± 28b

     
  

-

303 ± 23

272 ± 20b

a

a

 

a

TMa

 

OA

+

317 ± 41

190 ± 19b

     
  

-

285 ± 52

260 ± 31b

     

VT, sb, mL

HCl

+

n/a

135 ± 20

  

a

  
  

-

n/a

n/a

     
 

OA

+

n/a

95 ± 19d

     
  

-

n/a

n/a

     

VE, liters

HCl

+

8.8 ± 1.1

8.6 ± 1.5

a

a

 

a

 
  

-

8.5 ± 0.9c

7.6 ± 1.1c

     
 

OA

+

9.1 ± 1.2

7.7 ± 1.2

     
  

-

8.0 ± 1.0c

7.4 ± 0.6c

     

PaCO2, mm Hg

HCl

+

40 ± 6

45 ± 9

a

a

 

a

TMa

  

-

42 ± 9

54 ± 13c

     
 

OA

+

41 ± 9

43 ± 10

     
  

-

46 ± 10

54 ± 17c

     

Ptransp, mean, mbar

HCl

+

5.5 ± 3.0

5.5 ± 4.6

a

a

a

  
  

-

6.8 ± 3.3

8.1 ± 3.4

     
 

OA

+

2.1 ± 3.0

2.7 ± 3.4

     
  

-

0.5 ± 3.2

3.1 ± 3.5

     

PEEPI, dyn, mbar

HCl

+

0.0 ± 1.1

0.3 ± 0.3

     
  

-

0.7 ± 0.6

0.9 ± 0.9

     
 

OA

+

0.0 ± 1.6

0.8 ± 0.5

     
  

-

0.3 ± 0.3

0.0 ± 1.6

     

Ccw, mL/mbar

HCl

+

89.3 ± 39.3

n/a

  

a

  
  

-

96.8 ± 34.9

115.5 ± 64.3

     
 

OA

+

40.9 ± 14.8d

n/a

     
  

-

39.3 ± 11.2d

49.5 ± 27.6d

     

Clung, mL/mbar

HCl

+

19.5 ± 4.0

n/a

a

 

a

  
  

-

16.4 ± 8.4

13.5 ± 2.8

     
 

OA

+

21.3 ± 4.7d

n/a

     
  

-

21.7 ± 8.3d

16.2 ± 7.9d

     

R, mbar/L per second

HCl

+

7.0 ± 0.7b

n/a

  

a

a

 
  

-

7.5 ± 1.6b

8.5 ± 2.8

     
 

OA

+

8.5 ± 1.0b

n/a

     
  

-

9.0 ± 3.0b

11.9 ± 2.7

     

EELV, mL

HCl

+

 

606 ± 171

  

a

a

 
  

-

 

372 ± 130c

     
 

OA

+

 

439 ± 90d

     
  

-

 

192 ± 51c, d

     
  1. Pre-acute lung injury (ALI) (Table S2 in additional data file 1) was tested only against baseline ALI. Post hoc testing was always performed if a significant F ratio for a factor or the interaction of factors was obtained by repeated measures analysis of variance (aP < 0.05), but only significant differences are marked: bP < 0.05 for within-group differences (ALI versus Treatment), cP < 0.05 for between-group differences (PCV + SB versus PCV – SB), and dP < 0.05 for between-group differences (HCl-ALI versus OA-ALI) (post hoc Tukey multiple comparison test). +, pressure-controlled ventilation with maintained spontaneous breathing; -, pressure-controlled ventilation without spontaneous breathing; Ccw, chest wall compliance; Clung, lung compliance; EELV, end-expiratory lung volume; HCl, hydrochloric acid-induced acute lung injury; M, mode; n/a, not applicable; OA, oleic acid-induced acute lung injury; PaCO2, arterial partial pressure of carbon dioxide; PCV + SB, pressure-controlled ventilation with spontaneous breathing; PCV – SB, pressure-controlled ventilation without spontaneous breathing; PEEPI, dyn, dynamic intrinsic positive end-expiratory pressure; Ptransp, mean, mean transpulmonary airway pressure; R, respiratory system resistance; RR, respiratory rate; SB, spontaneous breathing; T, time; VE, minute ventilation; VT, tidal volume; VT, sb, tidal volume of spontaneous breaths.