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Table 2 Selected quorum sensing inhibitors as potential therapeutic agents

From: Bench-to-bedside review: Quorum sensing and the role of cell-to-cell communication during invasive bacterial infection

Agent References Target Proposed mechanism of action Current status
Macrolide and aminoglycoside antibiotics [24, 66, 71] AHL signal generation Inhibit C12-homoserine lactone by Pseudomonas aeruginosa quorum sensing system Experimental use of existing antibiotics
S-adenosyl-homosysteine [70] AHL signal generation Inhibits generation of AHL by RhlI synthesis In vitro testing
Antibody to AHL [80] C12-homoserine lactone of P. aeruginosa Antibodies to AHL block cell to cell Signaling In vitro and animal models
AiiA degrading enzymes [70] AHL lactone ring Lactonolysis of AHL disrupts signaling potential In vitro testing; might be useful as topical agent
PvdQ-type degrading enzymes [70] Fatty acid side chain of AHL Aminoacylase releases fatty acid and destabilizes lactone ring In vitro studies
Halogenated furanones, other natural or synthetic AHL analogues [70, 72, 73, 75] AHL receptors and LuxR homologues Competitive inhibitors for AHL receptor binding In vitro and animal studies
RIP and similar RNAIII-inhibiting peptides [47, 76, 78, 79] TRAP in agr peptide system Inhibits phosphorylation of TRAP blocking RNAIII signaling In vitro and animal studies
RAP inhibitors [77] RNAIII-activating protein of staphylococci Bind RAP and block agr activation In vitro and animal studies
  1. agr, accessory gene regulator; AHL, N-acyl homoserine lactone; RAP, RNAIII-activating protein; RIP, RNAIII-inhibiting peptide; TRAP, target of RNAIII-activating protein.