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Table 1 Hemodynamic parameters of responders and nonresponders

From: Association between inflammatory mediators and response to inhaled nitric oxide in a model of endotoxin-induced lung injury

Parameter

Responder (n = 15)

Nonresponder (n = 13)

 

Baseline T0

Endotoxin

Inhaled nitric oxide

Baseline T0

Endotoxin

Inhaled nitric oxide

PaO2/FiO2 (mmHg)

502 ± 42

215 ± 118*

316 ± 141

462 ± 62

234 ± 119*

225 ± 126

PaCO2 (mmHg)

37 ± 3.0

50 ± 11*

49 ± 11

39 ± 4.8

47 ± 7.1*

51 ± 9.2

pH

7.51 ± 0.03

7.29 ± 0.10*

7.22 ± 0.29

7.50 ± 0.04

7.34 ± 0.08*

7.30 ± 0.08

CO (l/min)

4.2 ± 1.2

4.4 ± 0.9

4.6 ± 1.2

4.1 ± 0.9

5.0 ± 1.5

5.4 ± 1.7

MPAP (mmHg)

16 ± 1.6

40 ± 7.7*

30 ± 7.5

15 ± 2.3

33 ± 5.5*

28 ± 5.0

PVR (dyne/s/cm5)

222 ± 77

617 ± 231*

425 ± 179

186 ± 38

407 ± 172*

296 ± 125

CVP (mmHg)

4.0 ± 1.6

7.0 ± 3.0*

7.6 ± 3.9

4.8 ± 1.8

8.4 ± 3.2*

7.8 ± 2.8

MAP (mmHg)

85 ± 8.3

80 ± 17

77 ± 15

81 ± 9.8

78 ± 21

75 ± 22

SVR (dyne/s/cm5)

1,700 ± 436

1,380 ± 288

1,314 ± 341

1,541 ± 339

1,128 ± 256*

1,032 ± 292

Qs/Qt (%)

9.4 ± 2.8

30 ± 20*

23 ± 17

12 ± 4.1

24 ± 9.0*

29 ± 12

Crs (ml/cmH2O)

27 ± 3.8

12 ± 3.2*

Not measured

26 ± 4.0

13 ± 3.2*

Not measured

Rrs (cmH2O·s/l)

15 ± 4.0

29 ± 8.8*

Not measured

15 ± 2.8

29 ± 8.6*

Not measured

  1. Parameters were recorded at baseline T0, 4 hours after the start of endotoxin infusion, and after 15 minutes of nitric oxide inhalation. Data represent the mean ± standard deviation. CO, cardiac output; MPAP, mean pulmonary arterial pressure; PVR, pulmonary vascular resistance; CVP, central venous pressure; MAP, mean arterial pressure; SVR, systemic vascular resistance; Qs/Qt, intrapulmonary shunt; Crs, compliance of the respiratory system; Rrs, resistance of the respiratory system. *P < 0.05, endotoxin versus baseline; P < 0.05, inhaled nitric oxide versus endotoxin;P < 0.05, responder versus nonresponder.