Skip to main content

Table 1 Drugs recognized to exhibit altered nonrenal clearance in acute kidney injury in clinical studies

From: Clinical review: Drug metabolism and nonrenal clearance in acute kidney injury

Drug

Normal renal function

Acute kidney injury

End-stage renal disease

Imipenem

130 ml/minute [55–58]

90 to 95 ml/minute [8, 59]

50 ml/minute [8, 60, 61]

Meropenem

45 to 60 ml/minute [62–64]

40 to 60 ml/minute [65, 66]

30 to 35 ml/minute [63, 64]

Vancomycin

40 ml/minute [67]

15 ml/minute [7]

5 ml/minute [68, 69]