Table 2 Mean arterial pressure and rectal temperature of endotoxaemic rats: Mean arterial pressure (MAP) and rectal temperature (temp) in control animals, in animals receiving 1.5 mg/kg endotoxin over a 60 minute period (lipopolysaccharide (LPS) group), and in animals receiving endotoxin plus an infusion of 5 mg/kg/hour erythro-9-[2-hydroxyl-3-nonyl]-adenine (EHNA) (LPS + EHNA group). Data are mean ± standard error of the mean.
Parameter | Group | Time (minutes) | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Â | Â | 0 | 15 | 30 | 45 | 60 | 75 | 90 | 105 | 120 |
MAP | Control | 76.0 ± 1.6 | 76.5 ± 3.5 | 76.9 ± 3.7 | 82.1 ± 3.6 | 83.0 ± 3.6 | 79.6 ± 3.8 | 84.8 ± 2.9 | 83.4 ± 4.0 | 81.3 ± 4.1 |
|  | LPS | 78.8 ± 3.0 | 73.6 ± 3.9 | 82.4 ± 4.4 | 83.1 ± 4.9 | 90.4 ± 3.8 | 87.0 ± 6.5 | 86.8 ± 4.7 | 84.8 ± 4.3 | 81.6 ± 4.8 |
|  | LPS + EHNA | 77.4 ± 3.4 | 75.5 ± 2.7 | 76.6 ± 2.5 | 82.0 ± 2.8 | 83.5 ± 3.1 | 86.8 ± 2.9 | 90.3 ± 3.1 | 85.5 ± 3.3 | 83.6 ± 3.4 |
Temp | Control | 36.1 ± 0.3 | 35.8 ± 0.5 | 36.3 ± 0.4 | 36.4 ± 0.5 | 36.4 ± 0.3 | 36.3 ± 0.3 | 36.8 ± 0.3 | 36.9 ± 0.3 | 36.6 ± 0.3 |
|  | LPS | 36.8 ± 0.4 | 36.8 ± 0.5 | 37.0 ± 0.6 | 36.8 ± 0.4 | 37.3 ± 0.6 | 36.7 ± 0.6 | 36.7 ± 0.6 | 36.8 ± 0.5 | 36.8 ± 0.4 |
|  | LPS + EHNA | 36.4 ± 0.3 | 36.9 ± 0.3 | 37.8 ± 0.2 | 38.2 ± 0.2 | 37.9 ± 0.1 | 37.0 ± 0.3 | 37.7 ± 0.3 | 37.8 ± 0.2 | 37.4 ± 0.2 |