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Figure 5 | Critical Care

Figure 5

From: The adenosine deaminase inhibitor erythro-9-[2-hydroxyl-3-nonyl]-adenine decreases intestinal permeability and protects against experimental sepsis: a prospective, randomised laboratory investigation

Figure 5

Adenosine deaminase inhibition protects against intestinal mucosal damage during endotoxaemia. Representative microphotographs of haematoxylin & eosin (H & E) stained sections of the terminal ileum of experimental groups. (a,d) Control group with normal appearance of small intestinal mucosa with long villi that have occasional goblet cells, small and basal located nuclei of epithelial cells, and a normal lamina propria. (b, e) Lipopolysaccharide (LPS) group with disturb mucosal architecture showing plump villi with markedly increased villous stroma, a lifting of epithelial layer from the lamina propria (*subepithelial Gruenhagen's space), and a higher nucleus-plasma ratio of epithelial cells. (c, f) LPS + erythro-9-[2-hydroxyl-3-nonyl]-adenine (EHNA) group with a similar appearance of small intestinal mucosa as in the control group. (a-c) original magnification of ×16 and (d-F) ×64

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