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Figure 1 | Critical Care

Figure 1

From: The adenosine deaminase inhibitor erythro-9-[2-hydroxyl-3-nonyl]-adenine decreases intestinal permeability and protects against experimental sepsis: a prospective, randomised laboratory investigation

Figure 1

Endotoxaemic challenge (experimental design). Rats were randomised to three groups of eight animals each. After preparation, a 30 minute stabilisation period was allowed. The animals of group B (lipopolysaccharide (LPS) + erythro-9-[2-hydroxyl-3-nonyl]-adenine (EHNA)) received 5 mg/kg/hour EHNA intravenously as a continuous infusion over one hour. Endotoxaemia was induced immediately after baseline measurements by continuous intravenous infusion of LPS for 60 minutes. Animals of the control group received no EHNA or LPS. The same amount of fluids was infused in all rats for the total duration of the experiment (120 minutes).

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Critical Care

ISSN: 1364-8535