Acute kidney injury is common, parallels organ dysfunction or failure, and carries appreciable mortality in patients with major burns: a prospective exploratory cohort study

Table 3 Characteristics, baseline, and outcome of the patients who developed acute kidney injury classified by RIFLE (n = 31)

	Risk (n = 15)	Injury (n = 10)	Failure (n = 6)	P value
Age, years	47.7 (36.1 to 59.2)	56.9 (42.7 to 71.1)	70.5 (55.1 to 85.9)	0.07
Total body surface area, percentage burned	45.6 (32.5 to 58.7)	56.5 (37.1 to 75.9)	35.8 (17.8 to 53.9)	0.25
Full thickness burns, percentage	32.4 (19.9 to 44.8)	36.0 (17.2 to 54.9)	24.3 (14.4 to 34.3)	0.60
Gender, female/male	6/9	2/8	2/4	0.58
Mortality	2	4	5	0.01
Dialysis	-	-	4
Recovery	13	5^a	2^b	0.04
Multiple organ failure	9	9	6	0.07
Lowest mean arterial pressure, mm Hg	56.0 (53.2 to 58.8)	62.2 (56.1 to 68.3)	57.2 (52.4 to 61.9)	0.06
Adrenergic drugs on days 1–3^c	11	5	5	0.31
Mechanical ventilation	15	9	6	0.34^d
Length of stay for survivors, days	69.2 (40.0 to 98.3)	66.8 (17.2 to 116.4)	46	0.90

Data are mean (95% confidence interval) or number of patients. Acute kidney injury is classified by RIFLE (Risk, Injury, Failure, Loss of kidney function, and End-stage kidney disease). Multiple organ failure is 3 to 4 sequential organ failure assessment score points in more than one organ dimension. The lowest recorded mean arterial pressure from days 1 to 3 was used. ^aOne patient was transferred to another hospital before recovery. ^bThe patient who survived Failure was partially normalised after 7 weeks, and one patient whose recovery was complete after 9 weeks died after 16 weeks. ^cNumber of patients who required adrenergic drugs during days 1 to 3. We used contingency table Pearson chi-square test for categorical variables (^dthree of the six expected values were less than 1) and one-way analysis of variance for continuous data.

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