Acute kidney injury is common, parallels organ dysfunction or failure, and carries appreciable mortality in patients with major burns: a prospective exploratory cohort study

Table 2 Characteristics, baseline, and outcome of patients studied who were classified by RIFLE

	No AKI (n = 96)	AKI (n = 31)	P value	Adjusted
Age, years	35.9 (31.8 to 40.1)	55.1 (47.4 to 62.7)	<0.001
Total body surface area, percentage burned	35.8 (33.0 to 38.5)	47.2 (38.3 to 56.1)	0.001
Full thickness burns, percentage	13.6 (10.9 to 16.4)	32.0 (24.0 to 40.0)	<0.001
Gender, female/male	22/74	10/21	0.30
Mortality	7 (7.3%)	11 (35.5%)	<0.001
Multiple organ failure	3 (3.1%)	24 (77.4%)	<0.001
Mechanical ventilation	51 (53.1%)	30 (96.8%)	<0.001
Length of stay for survivors, days	39.9 (32.5 to 47.3)	67.3 (46.0 to 88.6)	0.004
Baseline laboratory variables
Plasma creatinine, μmol/L	81.3 (76.4 to 86.1)	82.3 (72.0 to 92.5)	0.85	0.87
Platelet count, × 10⁹/L	238 (218 to 259)	278 (231 to 326)	0.08	0.14
Plasma bilirubin, μmol/L	18.9 (15.5 to 22.3)	24.0 (17.3 to 30.6)	0.13	0.21
Worst laboratory value during the first week
Lowest platelet count, × 10⁹/L	120 (106 to 133)	68 (48 to 87)	<0.001	0.001
Plasma bilirubin, μmol/L	19.9 (16.7 to 23.0)	37.4 (26.1 to 48.6)	<0.001	0.001

Data are mean (95% confidence interval) or number (percentage). Acute kidney injury (AKI) is classified by RIFLE (Risk, Injury, Failure, Loss of kidney function, and End-stage kidney disease). Multiple organ failure is 3 to 4 sequential organ failure assessment score points in more than one organ dimension. Worst laboratory value is the highest value for bilirubin and the lowest value for platelet count. We used contingency table Pearson chi-square test for categorical variables, Student t test for continuous data, and analysis of covariance (with P value from post hoc analysis between AKI and no AKI) to adjust for age and for percentage burned of total body surface area.

ISSN: 1364-8535