Variable | Standard treatment (n = 250) | Intensive treatment (n = 254) | P value† |
---|---|---|---|
Length of stay in ICU (days) | |||
Median (Interquartile range) | 6 (3 to 11) | 6 (3 to 12) | 0.351 |
Duration of ventilatory support (days) | |||
Median (Interquartile range) | 5 (2 to 9) | 6 (2 to 10) | 0.857 |
Ventilatory support (%) | 238 (95.2) | 238 (93.7) | 0.476 |
Dopamine (%) | 190 (76) | 182 (71.7) | |
Dosage (μg/kg/minute) *‡ | 14.45 ± 8.97 | 14.85 ± 8.99 | 0.366 |
Norepinephrine (%) | 68 (27.2) | 55 (21.7) | |
Dosages (μg/kg/minute) *‡ | 0.36 ± 0.77 | 0.36 ± 0.56 | 0.993 |
Epinephrine (%) | 44 (17.6) | 46 (18.1) | |
Dosages (μg/kg/minute) *‡ | 0.34 ± 0.40 | 0.31 ± 0.59 | 0.613 |
Dobutamine (%) | 9 (3.6) | 14 (5.5) | |
Dosages (μg/kg/minute) *‡ | 4.97 ± 2.43 | 8.43 ± 6.48 | 0.060 |
Swan Ganz (%) | 28 (11.2) | 30 (11.8) | 0.800 |
Renal impairment (%) § | 25 (10) | 32 (12.6) | 0.357 |
Renal-replacement therapy (%) | 33 (13) | 27 (10.8) | 0.447 |
Hydrocortisone (%) | 66 (26.4) | 67 (26.3) | 0.996 |
Ventilator associated pneumonia (%) | 55 (22) | 43 (16.9) | 0.15 |
Catheter-related infection (%) | 9 (3.6) | 6 (2.4) | 0.414 |
Urinary infections (%) | 11 (4.4) | 13 (5.1) | 0.705 |
Primary bacteraemia (%) | 8 (3.2) | 7 (2.8) | 0.769 |
Treatment with antibiotics for ≥ 8 days (%) | 183 (73.2) | 186(73.2) | 0.994 |
Red-cell transfusions | |||
Patients requiring transfusions (%) | 91 (36) | 99 (39) | 0.551 |
No. of transfusions/patients* | 6 ± 5.5 | 4.9 ± 4.1 | 0.412 |