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Table 5 Processed EEG and physiological parameters 2 minutes before endotracheal suctioning, with and without medication given up to 10 minutes before endotracheal suctioning

From: Entropy and bispectral index for assessment of sedation, analgesia and the effects of unpleasant stimuli in critically ill patients: an observational study

Variable Without medication With medication P Test
N 282 103   
Response entropy 91 (47 to 97) 82 (39 to 97) 0.111 Mann-Whitney
State entropy 78 (42 to 87) 66 (31 to 85) 0.101 Mann-Whitney
BIS-Index 80 (57 to 93) 76 (49 to 91) 0.078 Mann-Whitney
Heart rate (beats/minute) 83 (70 to 99) 91 73–100) 0.09 Mann-Whitney
etCO2 (mmHg) 37 (33.44) 41 (34 to 53) < 0.01 Mann-Whitney
FiO2 (%) 40 (38 to 49) 47 (38 to 58) 0.02 Mann-Whitney
Respiratory rate (breaths/minute) 14.0 (11.0 to 18.0) 14.5 (11.6 to 19.0) 0.43 Mann-Whitney
SpO2 (%) 95 (93 to 79) 95 (93 to 97) 0.92 Mann-Whitney
SBP (mmHg) 116 (103 to 138) 117 (103 to 134) 0.83 Mann-Whitney
MBP (mmHg) 74 (67 to 83) 75 (65 to 81) 0.45 Mann-Whitney
DBP (mmHg) 55 (49 to 61) 53 (44 to 60) 0.19 Mann-Whitney
RSS score 2 (2 to 4; n = 147) 3 (2 to 4; n = 61) 0.25 Mann-Whitney
Age (years) 66.6 ± 12.3 60.0 ± 10.9 0.11 t-test
SAPS II score 47.7 ± 19.2 42.2 ± 16.0 0.40 t-test
LOS (minutes) 10,750 (5,230 to 195,90) 10,305 (6,600 to 12,210) 0.99 Mann-Whitney
  1. Because of the unbalanced numbers of events, age, SAPS and LOS were divided into two groups: endotracheal suctioning without medication or with medication less than 50% of the time, and endotracheal suctioning with medication more than 50% of the time or always with medication. Values are expressed as median (interquartile range) or as mean ± standard deviation. BIS, bispectral index; DBP, diastolic blood pressure; EEG, electroencephlogram; etCO2, end-tidal barbon dioxide; FiO 2, fractional inspired oxygen; LOS, length of stay; MBP, mean blood pressure; RSS, Ramsay Sedation Scale; SAPS, Simplified Acute Physiology Score; SBP, systolic blood pressure; SpO2, pulse oximetry.