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Table 3 Processed EEG and physiological variables and RSS score 2 minutes before sedation boli

From: Entropy and bispectral index for assessment of sedation, analgesia and the effects of unpleasant stimuli in critically ill patients: an observational study

Variable Indication P Test
  Agitation with threat Agitation Medical reasons Anticipated nursing procedure No annotation   
n 20 129 86 116 57   
Response entropy 91 (61 to 97) 91 (44 to 98) 35 (22 to 65) 48 (28 to 96) 65 (32 to 96) < 0.001 Kruskal-Wallis
State entropy 79 (54 to 86) 79 (40 to 88) 32 (21 to 56) 43 (26 to 74) 59 (29 to 85) < 0.001 Kruskal-Wallis
BIS-Index 81 (71 to 91) 76 (54 to 91) 48 (40 to 62) 57 (47 to 72) 72 (46 to 92) < 0.001 Kruskal-Wallis
RSS score 1 (1 to 2) 2 (1 to 4 to) 4 (3 to 5) 4 (2 to 4) 4 (2 to 4) < 0.001 Kruskal-Wallis
Heart rate (beats/minute) 83 (69 to 104) 90 (73 to 104) 96 (90 to 107) 92 (72 to 100) 96 (85 to 107) 0.011 Kruskal-Wallis
etCO2 (mmHg) 45 (37 to 62) 42 (34 to 55) 47 (35 to 57) 41 (36 to 53) 34 (33 to 50) 0.043 Kruskal-Wallis
FiO2 (%) 48 (40 to 62) 47 (39 to 58) 50 (39 to 61) 48 (40 to 59) 39 (38 to 54) 0.062 Kruskal-Wallis
Respiratory rate (breaths/minute) 19.0 (16.3 to 19.8) 15.5 (12.0 to 20.0) 17.8 (12.0 to 20.0) 14.3 (11.8 to 18.3) 17.7 (11.7 to 20.4) 0.025 Kruskal-Wallis
SpO2 (%) 95 (92 to 98) 96 (92 to 98) 97 (95 to 98) 95 (93 to 98) 96 (95 to 98) 0.116 Kruskal-Wallis
SBP (mmHg) 115 ± 22 113 ± 21 96 ± 28 110 ± 26 113 ± 29 < 0.001 RM-ANOVA
MBP (mmHg) 79 (71 to 82) 70 (63 to 79) 63 (57 to 69) 69 (59 to 79) 70 (63 to 84) < 0.001 Kruskal-Wallis
DBP (mmHg) 60 (55 to 64) 50 (44 to 59) 46 (39 to 52) 50 (41 to 58) 52 (45 to 60) < 0.001 Kruskal-Wallis
  1. The sedation boli were given for various indications, according to the nurses' notes. Values are expressed as median (interquartile range) or as mean ± standard deviation. BIS, bispectral index; SBP, MBP, DBP, systolic, mean, diastolic blood pressure; EEG, electroencephlogram; etCO2, end-tidal barbon dioxide; FiO 2, fractional inspired oxygen; RM-ANOVA, repeated measures analysis of variance; RSS, Ramsay Sedation Scale; SpO2, pulse oximetry.