ADDRESS | PROWESS | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
Enrollment sequence within a site | Placebo | DrotAA | Placebo | DrotAA | ||||||
Number | Mortality percentage | Number | Mortality percentage | RR (95% CI) | Number | Mortality percentage | Number | Mortality percentage | RR (95% CI) | |
1st to 4th patients | 727 | 15.5% | 741 | 20.1% | 1.29 (1.04, 1.62) | 279 | 31.5% | 280 | 28.6% | 0.91 (0.71, 1.17) |
5th to 8th patients | 303 | 17.5% | 284 | 17.3% | 0.99 (0.69, 1.40) | 179 | 29.6% | 183 | 24.4% | 0.81 (0.58, 1.14) |
9th to 12th patients | 132 | 19.7% | 142 | 16.2% | 0.82 (0.49, 1.37) | 128 | 25.8% | 121 | 20.7% | 0.80 (0.51, 1.26) |
>12th patients | 135 | 21.5% | 149 | 14.8% | 0.69 (0.42, 1.14) | 254 | 33.5% | 266 | 22.9% | 0.69 (0.52, 0.91) |