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Figure 5 | Critical Care

Figure 5

From: Influence of enrollment sequence effect on observed outcomes in the ADDRESS and PROWESS studies of drotrecogin alfa (activated) in patients with severe sepsis

Figure 5

Twenty-eight-day mortality in all randomly assigned medical patients with single organ dysfunction in ADDRESS (c) and PROWESS (d) with no patients removed from the analysis and also with the first through fourth patients enrolled at each site removed. Note: 0 represents the results for the entire population, and 1 through 4 correspond to the analysis with the first through fourth patients from each site removed. ADDRESS, ADministration of DRotrecogin alfa (activated) in Early Stage Severe Sepsis; DrotAA, drotrecogin alfa (activated); OD, organ dysfunction; PBO, placebo; PROWESS, Protein C Worldwide Evaluation in Severe Sepsis.

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