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Table 7 Performance of various values of PetCO2 and duration of CPR for prediction of ROSC in patients with shockable initial rhythm in cardiac arrest

From: Partial pressure of end-tidal carbon dioxide successful predicts cardiopulmonary resuscitation in the field: a prospective observational study

PetCO2 Cut-off (kPa [mmHg]) n Min-max (kPa [mmHg]) Mean ± SD (kPa [mmHg]) Sensitivity (%) Specificity (%) PPV (%) NPV (%) AUROC (95% CI)
Initial ≤1.3 (10) 71 0.0–1.3 (0.0–10) 0.69 ± 0.3 (5.2 ± 2.6) 100 76 91 100 0.93 (0.86–0.97)
  >1.3 (10) 233 1.4–8.7 (10.1–65.4) 2.59 ± 1.08 (19.6 ± 8.3)      
0–10 minute (average) ≤1.6 (12.1) 86 0.3–1.6 (2.8–12.1) 0.96 ± 0.33 (7.22 ± 3.1) 100 92 97 100 0.99 (0.99–1.00)
  >1.6 (12.1) 218 1.7–4.8 (12.2–39.1) 2.83 ± 0.77 (21.1 ± 5.8)      
10 minute ≤1.5 (11.3) 72 0.3–1.5 (2.6–11.3) 0.96 ± 0.37 (7.2 ± 2.9) 100 77 91 100 0.99 (0.98–0.99)
  >1.5 (11.3) 232 1.6–5.8 (11.4–43.6) 3.17 ± 0.96 (24.1 ± 7.3)      
11–15 minute (average) ≤1.6 (12.1) 93 0.4–1.6 (3.7–12.1) 0.99 ± 0.28 (7.5 ± 2.1) 100 100 100 100 1.00 (1.00–1.00)
  >1.6 (12.1) 211 1.8–5.5 (13.5–41.4) 3.22 ± 0.74 (24.1 ± 8.3)      
15 minute ≤1.8 (13.5) 92 0.2–1.8 (1.6–13.5) 1.11 ± 0.39 (7.9 ± 2.9) 100 99 100 100 1.00 (1.00–1.00)
  >1.8 (13.5) 212 1.9–7.7 (13.6–59.3) 3.71 ± 0.99 (27.8 ± 7.3)      
20 minute ≤1.5 (11.3) 93 0.3–1.5 (2.8–11.3) 0.95 ± 0.26 (7.3 ± 2.2) 100 100 100 100 1.00 (1.00–1.00)
  >1.5 (11.3) 211 2.1–7.3 (11.4–54.9) 4.33 ± 1.11 (32.3 ± 7.9)      
Max ≤2.3 (17.3) 83 0.7–2.3 (5.26–17.3) 1.56 ± 0.34 (13.2 ± 3.4) 100 89 95 100 0.99 (0.90–1.00)
  >2.3 (17.3) 221 2.4–10.6 (17.4–79.7) 5.23 ± 1.5 (39.2 ± 11.3)      
Final ≤1.5 (11.3) 93 0.3–1.5 (2.6–11.3 1.0 ± 0.32 (7.5 ± 1.9) 100 100 100 100 1.00 (1.00–1.00)
  >1.5 (11.3) 211 1.9–6.3 (11.3–47.4) 3.69 ± 0.94 (27.8 ± 7.1)      
  1. 'Shockable' was defined as ventricular fibrillation or tachycardia. AUROC, area under the receiver operating characteristic curve; CI, confidence interval; CPR, cardiopulmonary resuscitation; NPV, negative predictive value; PetCO2, partial pressure of end-tidal carbon dioxide; PPV, positive predictive value; ROSC, restoration of spontaneous circulation; SD, standard deviation.