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Table 3 Performance of various values of PetCO2 and duration of CPR for predicting ROSC in all patients with cardiac arrest

From: Partial pressure of end-tidal carbon dioxide successful predicts cardiopulmonary resuscitation in the field: a prospective observational study

PetCO2 Cut-off (kPa [mmHg]) n Min-max (kPa [mmHg]) Mean ± SD (kPa [mmHg]) Sensitivity (%) Specificity (%) PPV (%) NPV (%) AUROC (95% CI)
Initial ≤1.3 (≤10) 168 0.0–1.3 (0.0–10) 0.68 ± 0.34 (5.1 ± 2.5) 100 50 71 100 0.68 (0.63–0.72)
  >1.3 (>10) 569 1.4–8.7 (10.1–65.4) 3.52 ± 1.93 (26.3 ± 14.5)      
0 to 10 minutes ≤1.6 (≤12.1) 306 0.3–1.6 (2.3–12.1) 0.96 ± 0.34 (7.2 ± 2.6) 100 91 93 100 0.99 (0.99–1.00)
  >1.6 (>12.1) 431 1.7–5.6 (12.2–42.1) 2.79 ± 0.82 (20.9 ± 0.8)      
10 minutes ≤1.3 (≤9.8) 202 0.3–1.3 (2.3–9.8) 0.85 ± 0.31 (6.4 ± 2.1) 100 60 75 100 0.99 (0.98–0.99)
  >1.3 (>9.8) 535 1.4–7.2 (9.9–54.2) 2.89 ± 1.09 (21.7 ± 8.2)      
11–15 minutes ≤1.7 (≤12.8) 333 0.4–1.7 (3.1–12.8) 0.99 ± 0.30 (7.6 ± 2.2) 100 99 99 100 1.00 (0.99–1.00)
  >1.7 (>12.8) 404 1.8–5.5 (12.8–41.4) 3.19 ± 0.77 (23.9 ± 4.8)      
15 minutes ≤1.8 (≤13.6) 328 0.2–1.8 (1.5–13.5) 1.11 ± 0.39 (8.4 ± 2.8) 100 98 98 100 0.99 (0.99–1.00)
  >1.8 (>13.6) 409 1.9–7.7 (13.6–57.9) 3.65 ± 0.98 (27.8 ± 7.4)      
20 minutes ≤1.9 (≤14.3) 335 0.3–1.9 (2.3–14.3) 0.92 ± 0.29 (6.8 ± 2.1) 100 100 100 100 1.00 (1.00–1.00)
  >1.9 (>14.3) 402 2.1–7.8 (14.4–58.7) 4.36 ± 1.11 (33.1 ± 8.4)      
Maximal ≤2.3 (≤17.3) 293 0.7–2.3 (5.3–17.3) 1.58 ± 0.34 (12.1 ± 2.6 100 87 91 100 0.99 (0.99–1.00)
  >2.3 (>17.3) 444 2.4–10.7 (18.1–80.5) 5.12 ± 1.57 (38.4 ± 11.9)      
Final ≤1.7 (≤12.8) 335 0.2–1.7 (1.7–12.8) 0.98 ± 0.33 (7.4 ± 3.2) 100 99 99 100 1.00 (1.00–1.00)
  >1.7 (>12.8) 402 1.9–6.6 (14.3–49.7) 0.98 ± 0.33 (27.8 ± 7.2)      
  1. AUROC, area under the receiver operating characteristic curve; CI, confidence interval; CPR, cardiopulmonary resuscitation; NPV, negative predictive value; PetCO2, partial pressure of end-tidal carbon dioxide; PPV, positive predictive value; ROSC, return of spontaneous circulation; SD, standard deviation