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Table 4 Parameters of right ventricular oxygen balance in animals subjected to acute pulmonary hypertension

From: Effects of inhaled iloprost on right ventricular contractility, right ventriculo-vascular coupling and ventricular interdependence: a randomized placebo-controlled trial in an experimental model of acute pulmonary hypertension

Parameter

Treatment

Baseline

Pulmonary hypertension

   

Pre-inhalation

5 minutes after inhalation

RCA-PP (mmHg)

Iloprost

86 ± 15

61 ± 22*

78 ± 18* †‡

 

Control

73 ± 13

51 ± 9*

53 ± 12*

RPP (bpm·mmHg)

Iloprost

2,105 ± 342

4,390 ± 766*

2,904 ± 727* †‡

 

Control

2,343 ± 816

4,373 ± 997*

4,414 ± 995*

ΔHR·PVA (%)

Iloprost

100 ± 0

191 ± 66*

122 ± 29†‡

 

Control

100 ± 0

188 ± 44*

197 ± 49*

  1. Values are shown for baseline and in pulmonary hypertension before inhalation and 5 minutes after inhalation of either iloprost or control. For the complete experimental time course, see Additional file 5. Values are expressed as mean ± standard deviation. *P < 0.05 versus baseline; †P < 0.05 versus before inhalation; ‡P < 0.05 iloprost versus control (corrected for multiple comparisons). bpm, beats/minute; ΔHR·PVA, changes in the product of heart rate and pressure-volume area; RCA-PP, right coronary artery perfusion pressure; RPP, right ventricular rate pressure product.
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Critical Care

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