Effects of inhaled iloprost on right ventricular contractility, right ventriculo-vascular coupling and ventricular interdependence: a randomized placebo-controlled trial in an experimental model of acute pulmonary hypertension

Table 1 Respirator settings and arterial blood gas status in animals subjected to acute pulmonary hypertension

Parameter	Treatment	Baseline	Pulmonary hypertension
			Pre-inhalation	5 minutes after inhalation
RR (breaths/minute)	Iloprost	17 ± 1	17 ± 1	17 ± 1
	Control	17 ± 1	17 ± 1	17 ± 2
V_T (ml/kg)	Iloprost	10 ± 1	10 ± 1	10 ± 1
	Control	11 ± 1	10 ± 1	10 ± 1
FiO₂ (%)	Iloprost	37 ± 9	15 ± 2*	15 ± 2*
	Control	35 ± 8	15 ± 1*	15 ± 1*
PO₂ (mmHg)	Iloprost	161 ± 38	43 ± 4*	43 ± 4*
	Control	161 ± 46	47 ± 5*	44 ± 5*
PCO₂ (mmHg)	Iloprost	38 ± 2	38 ± 2	41 ± 4
	Control	40 ± 4	37 ± 2	39 ± 3
PH	Iloprost	7.46 ± 0.06	7.45 ± 0.07	7.41 ± 0.08
	Control	7.45 ± 0.04	7.47 ± 0.06	7.47 ± 0.04

Values are shown for baseline and in pulmonary hypertension before inhalation and 5 minutes after inhalation of either iloprost or control. For the complete experimental time course, see Additional file 1. Values are expressed as mean ± standard deviation. *P < 0.05 versus baseline (corrected for multiple comparisons). FiO₂, fraction of inspired oxygen; P(C)O₂, arterial partial pressure of oxygen (carbon dioxide); RR, respiratory rate; V_T, tidal volume.

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