The effects of inhaled iloprost on ventricular interdependence. Shown are the effects of inhaled iloprost on end-diastolic and endsystolic volumes in the (a) right ventricle and (b) left ventricle in animals with PHT. Data are expressed as mean ± standard deviation. *P < 0.05 versus BL; †P < 0.05 versus before inhalation; ‡P < 0.05, ILO versus C (adjusted for multiple comparisons). In addition, P values of the repeated measures analysis of variance are shown separately for the time, group and INT (time × group) effects. BL, baseline; EDV, end-diastolic volume; ESV, end-systolic volume; ILO, iloprost; INT, interaction; LV, left ventricular; PHT, pulmonary hypertension; RV, right ventricular.