Figure 2From: Bench-to-bedside review: Optimising emergency reversal of vitamin K antagonists in severe haemorrhage – from theory to practice Calculation of prothrombin complex concentrate dose for anticoagulant reversal in bleeding patients [2]. The proposed 'calculation of dose' method is difficult to manage in an emergency situation when immediate normalisation of the international normalised ratio (INR) is required to stop life-threatening bleeding. Reproduced with permission from Massachusetts Medical Society.Back to article page