|
Mean arterial pressure (mmHg)
|
Controls
|
125 ± 4
|
64 ± 7
|
59 ± 6
| |
| |
Bosentan
|
141 ± 7
|
73 ± 5
|
61 ± 6
| |
|
Mean pulmonary artery pressure (mmHg)
|
Controls
|
28 ± 2
|
35 ± 2
|
34 ± 2
|
***
|
| |
Bosentan
|
27 ± 2
|
34 ± 2
|
20 ± 1
| |
|
Pulmonary vascular resistance index (mmHg kg min/ml)
|
Controls
|
182 ± 23
|
349 ± 52
|
398 ± 68
|
***
|
| |
Bosentan
|
155 ± 29
|
262 ± 47
|
97 ± 19
| |
|
Cardiac index (ml/min/kg)
|
Controls
|
111 ± 5
|
74 ± 6
|
65 ± 8
|
**
|
| |
Bosentan
|
130 ± 13
|
85 ± 10
|
130 ± 16
| |
|
Stroke volume index (ml/beat/kg)
|
Controls
|
0.71 ± 0.07
|
0.43 ± 0.04
|
0.34 ± 0.06
|
*
|
| |
Bosentan
|
0.87 ± 0.13
|
0.52 ± 0.09
|
0.69 ± 0.09
| |
|
Systemic vascular resistance index (mmHg kg min/ml)
|
Controls
|
1100 ± 56
|
830 ± 100
|
840 ± 69
|
**
|
| |
Bosentan
|
1100 ± 120
|
870 ± 100
|
450 ± 66
| |
|
Oxygen delivery index (ml/min/kg)
|
Controls
|
18 ± 1
|
13 ± 1
|
11 ± 1
|
**
|
| |
Bosentan
|
19 ± 2
|
13 ± 1
|
18 ± 2
| |
