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Table

From: Cardiopulmonary dysfunction during porcine endotoxin shock is effectively counteracted by the endothelin receptor antagonist bosentan

Parameter

Group

T0 h

T2 h

T5 h

 

Mean arterial pressure (mmHg)

Controls

125 ± 4

64 ± 7

59 ± 6

 
 

Bosentan

141 ± 7

73 ± 5

61 ± 6

 

Mean pulmonary artery pressure (mmHg)

Controls

  28 ± 2

35 ± 2

34 ± 2

***

 

Bosentan

  27 ± 2

34 ± 2

20 ± 1

 

Pulmonary vascular resistance index (mmHg kg min/ml)

Controls

  182 ± 23

349 ± 52

398 ± 68

***

 

Bosentan

  155 ± 29

262 ± 47

  97 ± 19

 

Cardiac index (ml/min/kg)

Controls

111 ± 5

74 ± 6

65 ± 8

**

 

Bosentan

  130 ± 13

  85 ± 10

130 ± 16

 

Stroke volume index (ml/beat/kg)

Controls

    0.71 ± 0.07

  0.43 ± 0.04

  0.34 ± 0.06

*

 

Bosentan

    0.87 ± 0.13

  0.52 ± 0.09

  0.69 ± 0.09

 

Systemic vascular resistance index (mmHg kg min/ml)

Controls

1100 ± 56

  830 ± 100

840 ± 69

**

 

Bosentan

  1100 ± 120

  870 ± 100

450 ± 66

 

Oxygen delivery index (ml/min/kg)

Controls

  18 ± 1

13 ± 1

11 ± 1

**

 

Bosentan

  19 ± 2

13 ± 1

18 ± 2

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