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Table

From: Cardiopulmonary dysfunction during porcine endotoxin shock is effectively counteracted by the endothelin receptor antagonist bosentan

Parameter Group T0 h T2 h T5 h  
Mean arterial pressure (mmHg) Controls 125 ± 4 64 ± 7 59 ± 6  
  Bosentan 141 ± 7 73 ± 5 61 ± 6  
Mean pulmonary artery pressure (mmHg) Controls   28 ± 2 35 ± 2 34 ± 2 ***
  Bosentan   27 ± 2 34 ± 2 20 ± 1  
Pulmonary vascular resistance index (mmHg kg min/ml) Controls   182 ± 23 349 ± 52 398 ± 68 ***
  Bosentan   155 ± 29 262 ± 47   97 ± 19  
Cardiac index (ml/min/kg) Controls 111 ± 5 74 ± 6 65 ± 8 **
  Bosentan   130 ± 13   85 ± 10 130 ± 16  
Stroke volume index (ml/beat/kg) Controls     0.71 ± 0.07   0.43 ± 0.04   0.34 ± 0.06 *
  Bosentan     0.87 ± 0.13   0.52 ± 0.09   0.69 ± 0.09  
Systemic vascular resistance index (mmHg kg min/ml) Controls 1100 ± 56   830 ± 100 840 ± 69 **
  Bosentan   1100 ± 120   870 ± 100 450 ± 66  
Oxygen delivery index (ml/min/kg) Controls   18 ± 1 13 ± 1 11 ± 1 **
  Bosentan   19 ± 2 13 ± 1 18 ± 2