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Table 5 Systemic changes during barbiturate coma

From: Pentobarbital versus thiopental in the treatment of refractory intracranial hypertension in patients with traumatic brain injury: a randomized controlled trial

Parameter Pretreatment 1st day 2nd day 3rd day 4rd day
Cardiac output (l/minute)a
   Thiopental 6.8 ± 1.4 6.4 ± 1.5 6.0 ± 1.4 6.7 ± 1.5 6.6 ± 1.8
   Pentobarbital 7.4 ± 2.2 7.1 ± 1.9 6.5 ± 2.0 7 ± 1.4 6.1 ± 1.3
Cardiac index (l/minute per m2)
   Thiopental 3.6 ± 0.6 3.4 ± 0.6 3.1 ± 0.6 3.6 ± 1.6 3.5 ± 0.9
   Pentobarbital 3.8 ± 1.2 3.8 ± 0.8 3.4 ± 0.8 3.6 ± 0.7 3.2 ± 0.6
Peripheral venous resistance (dines/m2)
   Thiopental 1,015 ± 325 1,022 ± 347 1,140 ± 429 1,089 ± 289 1,029 ± 253
   Pentobarbital 952 ± 257 893 ± 210 1,003 ± 322 939 ± 261 914 ± 188
Pulmonary artery wedge pressure (mmHg)
   Thiopental 10.4 ± 4.5 9.6 ± 3.6 10.1 ± 4.1* 10.9 ± 4.6* 11.4 ± 3.5*
   Pentobarbital 11.6 ± 4.0 11.4 ± 3.1 12.8 ± 3.1 13.2 ± 2.1 13.9 ± 3.1
mBP (mmHg)b
   Thiopental 92 ± 11 75 ± 7 76 ± 9* 76 ± 6* 76 ± 8
   Pentobarbital 94 ± 10 74 ± 1 68 ± 10 70 ± 1 70 ± 10
NAD (μg/kg per minute)c
   Thiopental 0.18 ± 0.33 0.28 ± 0.27 0.37 ± 0.3* 0.46 ± 0.39 0.56 ± 0.63
   Pentobarbital 0.19 ± 0.18 0.55 ± 0.68 0.73 ± 0.69 0.60 ± 0.44 0.96 ± 0.79
PO2/FiO2d
   Thiopental 284 ± 130 300 ± 139 293 ± 132 285 ± 138 254 ± 119
   Pentobarbital 317 ± 127 304 ± 116 262 ± 125 211 ± 77 184 ± 92
Haemoglobin
   Thiopental 10.9 ± 1.6 10.7 ± 1.3 11 ± 1.2 10.8 ± 0.9 10.7 ± 1.4
   Pentobarbital 10.6 ± 1.2 10.1 ± 1.0 10.4 ± 1.1 10.5 ± 1.1 10.2 ± 1.2
Temperature (°C)e
   Thiopental 35.8 ± 0.5 34.6 ± 1.3 34.6 ± 3.4 34.9 ± 1.0 34.9 ± 1.0
   Pentobarbital 35.7 ± 1.0 34.6 ± 1.2 34.3 ± 1.3 34.4 ± 1.3 34.2 ± 1.1
  1. aCardiac output, cardiac index, peripheral venous resistance and pulmonary artery wedge pressure: the values are the mean values over 24 hours. bmBP: minimum value of the medium blood pressure during the day. cNAD: maximum dose of Noradrenaline bitartrate during the day. dPO2/FisO2: ratio of partial oxygen tension to inspired fractional oxygen tension at 8:00 am. eTemperature: value of the minimum central temperature. *P < 0.05.