Parameter | Pretreatment | 1st day | 2nd day | 3rd day | 4rd day |
---|---|---|---|---|---|
Cardiac output (l/minute)a | |||||
Thiopental | 6.8 ± 1.4 | 6.4 ± 1.5 | 6.0 ± 1.4 | 6.7 ± 1.5 | 6.6 ± 1.8 |
Pentobarbital | 7.4 ± 2.2 | 7.1 ± 1.9 | 6.5 ± 2.0 | 7 ± 1.4 | 6.1 ± 1.3 |
Cardiac index (l/minute per m2) | |||||
Thiopental | 3.6 ± 0.6 | 3.4 ± 0.6 | 3.1 ± 0.6 | 3.6 ± 1.6 | 3.5 ± 0.9 |
Pentobarbital | 3.8 ± 1.2 | 3.8 ± 0.8 | 3.4 ± 0.8 | 3.6 ± 0.7 | 3.2 ± 0.6 |
Peripheral venous resistance (dines/m2) | |||||
Thiopental | 1,015 ± 325 | 1,022 ± 347 | 1,140 ± 429 | 1,089 ± 289 | 1,029 ± 253 |
Pentobarbital | 952 ± 257 | 893 ± 210 | 1,003 ± 322 | 939 ± 261 | 914 ± 188 |
Pulmonary artery wedge pressure (mmHg) | |||||
Thiopental | 10.4 ± 4.5 | 9.6 ± 3.6 | 10.1 ± 4.1* | 10.9 ± 4.6* | 11.4 ± 3.5* |
Pentobarbital | 11.6 ± 4.0 | 11.4 ± 3.1 | 12.8 ± 3.1 | 13.2 ± 2.1 | 13.9 ± 3.1 |
mBP (mmHg)b | |||||
Thiopental | 92 ± 11 | 75 ± 7 | 76 ± 9* | 76 ± 6* | 76 ± 8 |
Pentobarbital | 94 ± 10 | 74 ± 1 | 68 ± 10 | 70 ± 1 | 70 ± 10 |
NAD (μg/kg per minute)c | |||||
Thiopental | 0.18 ± 0.33 | 0.28 ± 0.27 | 0.37 ± 0.3* | 0.46 ± 0.39 | 0.56 ± 0.63 |
Pentobarbital | 0.19 ± 0.18 | 0.55 ± 0.68 | 0.73 ± 0.69 | 0.60 ± 0.44 | 0.96 ± 0.79 |
PO2/FiO2d | |||||
Thiopental | 284 ± 130 | 300 ± 139 | 293 ± 132 | 285 ± 138 | 254 ± 119 |
Pentobarbital | 317 ± 127 | 304 ± 116 | 262 ± 125 | 211 ± 77 | 184 ± 92 |
Haemoglobin | |||||
Thiopental | 10.9 ± 1.6 | 10.7 ± 1.3 | 11 ± 1.2 | 10.8 ± 0.9 | 10.7 ± 1.4 |
Pentobarbital | 10.6 ± 1.2 | 10.1 ± 1.0 | 10.4 ± 1.1 | 10.5 ± 1.1 | 10.2 ± 1.2 |
Temperature (°C)e | |||||
Thiopental | 35.8 ± 0.5 | 34.6 ± 1.3 | 34.6 ± 3.4 | 34.9 ± 1.0 | 34.9 ± 1.0 |
Pentobarbital | 35.7 ± 1.0 | 34.6 ± 1.2 | 34.3 ± 1.3 | 34.4 ± 1.3 | 34.2 ± 1.1 |