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Table 4 Adverse events during barbiturate coma

From: Pentobarbital versus thiopental in the treatment of refractory intracranial hypertension in patients with traumatic brain injury: a randomized controlled trial

Adverse event Thiopental (n = 22) Pentobarbital (n = 22) P
Hypotensiona 21 20 1
Respiratory infectionb 18 17 1
Urinary infectionc 0 2 0.49
Positive blood culture 4 1 0.34
ICP catheter colonization 7 5 0.5
CNS infection (CSF)d 3 0 0.23
SOFA pree 7 (4.5 to 9.5) 8.0 (5.5 to 9.0) 0.57
SOFA maximumf 11 (10 to 12) 11 (10 to 12) 0.94
  1. aHypotension is defined as detection of a medium arterial blood pressure below 80 mmHg at any time during barbiturate coma. bRespiratory infection: presence of a positive sputum culture. cUrinary infection: presence of a positive urine culture. dCentral nervous system infection (CNS) infection (cerebrospinal fluid [CSF]): infection of the CNS with a positive culture in the CSF. eSOFA pre: value of the Sepsis related Organ-Failure Assessment (SOFA) score before the beginning of the barbiturate coma. fSOFA maximum: maximum value of the SOFA during the barbiturate coma, according the indication by Moreno and coworkers [16].