UFH (n = 20) | UFH + tirofiban (n = 20) | P value | |
---|---|---|---|
Platelet/Monocyte counts at the end of CRRT | |||
Platelet count, × 109/L, mean ± SD | 87 ± 41.1 | 158 ± 45.3 | 0.001 |
Monocyte count, × 106/L, mean ± SD | 945 ± 77.3 | 1,394 ± 151 | 0.012 |
Platelet-monocyte aggregates as a percentage, mean ± SD | 27.5 ± 9.3 | 3.9 ± 2.1 | 0.001 |
Bleeding events during CRRT | |||
Minor bleeding, number | 2 | 1 | 0.560 |
Major bleeding, number | 0 | 0 | 1 |
Platelet transfusions during CRRT | |||
Platelet units per patient per day, mean ± SD | 0.05 ± 0.02 | 0 | 0.016 |
Outcome | |||
Intensive care unit mortality rate, number (percentage) | 8 (40) | 7 (35) | 0.752 |
Hospital mortality rate, number (percentage) | 8 (40) | 7 (35) | 0.752 |
SAPS II predicted mortality rate as a percentage | 36.9 | 41.4 | - |
Observed-to-expected mortality ratio | 1.08 | 0.85 | - |
95% confidence interval for the observed-to-expected mortality ratio | 0.46, 1.97 | 0.34, 1.59 | - |