Probability of attaining pharmacodynamic target during entire dosing interval (T > MIC > 30%, 50%, and 100%) as a function of MIC for imipenem and meropenem at a dosage of 500 mg q6h. The 30% and 50% targets represent conservative estimates for bacteriostatic and bactericidal activity, respectively. Each curve shows the likelihood of the drug to stay above the target MIC for the entire dosing period based on the pathogen's MIC. Note the steep declines in probabilities for MIC values between 0.5 and 4. Reproduced with permission from Kuti et al. .